Sexual dysfunctions are associated with major depression, chronic inflammation and anticholinergic consumption in the real-world schizophrenia FACE-SZ national cohort. Running title: sexual dysfunctions in schizophrenia

Guillaume Fond (1, 2, 3) , O. Godin (4, 5) , M. Dumontaud (3) , C. Faget (3) , F. Schürhoff (6) , F. Berna (7) , Bruno Aouizerate (8) , D. Capdevielle (9) , I. Chereau (10) , T. d'Amato (11) , C. Dubertret (12) , J. Dubreucq (4) , S. Leignier (4) , J. Mallet (4, 12) , D. Misdrahi (4, 8) , C. Passerieux (4, 13) , R. Rey (4, 11) , A. Schandrin (4, 14) , A. Szoke (15) , M. Urbach (4, 13) , P. Vidailhet (4, 7) , M. Leboyer (4, 15) , C. Lançon (16, 3) , L. Boyer (3) , P.M. Llorca (10)

1 AMU - Aix Marseille Université
2 APHM - Assistance Publique - Hôpitaux de Marseille
3 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
4 Fondation FondaMental [Créteil]
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 Inserm U955 - Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18)
7 UNISTRA - Université de Strasbourg
8 UB - Université de Bordeaux
9 UM1 - Université Montpellier 1
10 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
11 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
12 UPD7 - Université Paris Diderot - Paris 7
13 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
14 UM - Université de Montpellier
15 UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12
16 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]

Background Sexual dysfunctions (SD) are frequent in schizophrenia (SZ) and associated with treatment withdrawal, however they remain under-explored and under-treated. To date, most of the studies have focused on SD as antipsychotics' side effects in therapeutic trials. Aims The objectives of the present study were to determine the SD prevalence in stabilized SZ outpatients and their clinical, pharmacological and biological correlates. Method Two hundred and thirty-seven participants (61.2% men) were consecutively included and received a thorough 2 days- clinical assessment including the self-reported Sexual Functioning Questionnaire (SFQ). SD was defined by a SFQ score ≥ 8. Results Two hundred and thirty-seven subjects were recruited in the FACE-SZ cohort, 41% of them reported sexual dysfunctions. In multivariate analyses, SD have been associated with current major depressive disorder (adjusted odd ratio aOR = 2.29[1.08–4.85], p = .03), anticholinergic prescription (aOR = 2.65, p = .02) and chronic low-grade inflammation (aOR = 2.09, p = .03) independently of age, gender, current cannabis use disorder and olanzapine prescription. No antipsychotic has been associated with increased or decreased SD rate. Conclusions SD are frequent in SZ subjects. Major depression, anticholinergic prescription and chronic low-grade peripheral inflammation may be the three targets of interest for addressing this specific issue.

Keywords: Sexual dysfunctions; Schizophrenia; Antipsychotics; Major depression; Inflammation

Domains: Life Sciences [q-bio]; Human health and pathology; Psychiatrics and mental health

Guillaume Fond, O. Godin, M. Dumontaud, C. Faget, F. Schürhoff, et al.. Sexual dysfunctions are associated with major depression, chronic inflammation and anticholinergic consumption in the real-world schizophrenia FACE-SZ national cohort. Running title: sexual dysfunctions in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, 94, pp.109654. ⟨10.1016/j.pnpbp.2019.109654⟩. ⟨hal-02473659⟩