Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database

Nathalie . Coulon (1) , Ophelia Godin (2) , Ewa Bulzacka (3) , Caroline Dubertret (4) , Jasmina Mallet (4) , Guillaume Fond (5, 6) , Lore Brunel (4) , Meja Andrianarisoa (4) , George Anderson (7) , Isabelle Chéreau (8) , Hélène Denizot (4) , Romain Rey (4) , Jean‐michel Dorey (9) , Christophe Lançon (10) , Catherine Faget (11) , Paul Roux (12) , Christine Passerieux (4) , Julien Dubreucq (13) , Sylvain Leignier (13) , Delphine Capdevielle (14) , Myrtille Andre (14) , Bruno Aouizerate (4) , David Misdrahi (4) , Fabrice Berna (15) , Pierre Vidailhet (4) , Marion Leboyer (16) , Franck Schürhoff (4)

1 Inserm U955 - Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18)
2 UPMC - Université Pierre et Marie Curie - Paris 6
3 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
4 Fondation FondaMental [Créteil]
5 AMU - Aix Marseille Université
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 CRC Scotland & London
8 Service de psychiatrie
9 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
10 Pôle de psychiatrie
11 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
12 LSCP - Laboratoire de sciences cognitives et psycholinguistique
13 UGA UFRM - Université Grenoble Alpes - UFR Médecine
14 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
15 FMTS - Fédération de Médecine Translationnelle de Strasbourg
16 IMRB - Institut Mondor de Recherche Biomédicale

Objective: To compare the clinical symptomatology in patients with Early-Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551). Method: In a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were assessed using standardized and extensive clinical and neuropsychological batteries: AOS with onset ≥ 18 years and EOS with onset < 18 years (including 22 VEOS < 13 years). Results: The importance of better diagnosing EOS group, and in particularly VEOS, appeared in a longer DUP Duration of Untreated Psychosis (respectively, 2.6 years ± 4.1

Domaines: Psychiatrie et santé mentale

Nathalie . Coulon, Ophelia Godin, Ewa Bulzacka, Caroline Dubertret, Jasmina Mallet, et al.. Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database. Brain and Behavior, 2020, ⟨10.1002/brb3.1495⟩. ⟨hal-02473667⟩