Roles of specific lipid species in the cell and their molecular mechanism, Prog Lipid Res, vol.62, pp.75-92, 2016. ,
Alzheimer's and prion diseases, Lipid rafts: structure, function and role in HIV, vol.4, pp.1-22, 2002. ,
The role of cholesterol in membrane fusion, Chem Phys Lipids, vol.199, pp.136-143, 2016. ,
Cholesterol homeostasis: How do cells sense sterol excess, Chem Phys Lipids, vol.199, pp.170-178, 2016. ,
Structural Stringency of Cholesterol for Membrane Protein Function Utilizing Stereoisomers as Novel Tools: A Review, Cholesterol Homeostasis: Methods and Protocols, vol.2017, pp.21-39 ,
Role of chirality in peptide-induced formation of cholesterol-rich domains, Biochem J, vol.390, pp.541-548, 2005. ,
The molecular structure of the liquidordered phase of lipid bilayers, J Am Chem Soc, vol.136, pp.725-732, 2014. ,
Two classes of cholesterol binding sites for the beta2AR revealed by thermostability and NMR, Biophys J, vol.107, pp.2305-2312, 2014. ,
Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor, Biophys J, vol.113, pp.2415-2424, 2017. ,
Structural basis of Smoothened regulation by its extracellular domains, Nature, vol.535, pp.517-522, 2016. ,
A cholesterol recognition motif in human phospholipid scramblase 1, Biophys J, vol.107, pp.1383-1392, 2014. ,
Molecular mechanisms of protein-cholesterol interactions in plasma membranes: Functional distinction between topological (tilted) and consensus (CARC/CRAC) domains, Chem Phys Lipids, vol.199, pp.52-60, 2016. ,
How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains, Front Physiol, vol.4, p.31, 2013. ,
Identification of novel cholesterol-binding regions in Kir2 channels, J Biol Chem, vol.288, pp.31154-31164, 2013. ,
A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor, Structure, vol.16, pp.897-905, 2008. ,
A mirror code for proteincholesterol interactions in the two leaflets of biological membranes, Sci Rep, vol.6, p.21907, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01772916
Structure of the mitochondrial translocator protein in complex with a diagnostic ligand, Science, vol.343, pp.1363-1366, 2014. ,
Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern, Endocrinology, vol.139, pp.4991-4997, 1998. ,
Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor, Sci Rep, vol.1, p.69, 2011. ,
Cholesterol and the activity of bacterial toxins, FEMS Microbiol Lett, vol.238, pp.281-289, 2004. ,
CH-pi hydrogen bonds in biological macromolecules, Phys Chem Chem Phys, vol.16, pp.12648-12683, 2014. ,
Lipid-protein interactions in biological membranes: a structural perspective, Biochim Biophys Acta, vol.1612, pp.1-40, 2003. ,
Brain Lipids in Synaptic Function and Neurological Disease. Clues to Innovative Therapeutic Strategies for Brain Disorders, 2015. ,
How membrane lipids control the 3D structure and function of receptors, AIMS Biophysics, vol.5, pp.22-35, 2018. ,
Cholesterol modulates bitter taste receptor function, Biochim Biophys Acta, vol.1858, pp.2081-2087, 2016. ,
Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain, Biochim Biophys Acta, vol.1851, pp.956-964, 2015. ,
Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization, J Biol Chem, vol.289, pp.31983-31994, 2014. ,
Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+-and voltage-gated K+ (BK) channels, J Biol Chem, vol.287, pp.20509-20521, 2012. ,
Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor, Mol Endocrinol, vol.19, pp.588-594, 2005. ,
Cholesterol and the interaction of proteins with membrane domains, Prog Lipid Res, vol.45, pp.279-294, 2006. ,
Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains, Biochemistry, vol.45, pp.6105-6114, 2006. ,
Amino acid distributions in integral membrane protein structures, Biochim Biophys Acta, vol.1512, pp.1-14, 2001. ,
Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics, PLoS One, vol.11, p.166196, 2016. ,
The role of receptor topology in the vitamin D3 uptake and Ca(2+) response systems, Biochem Biophys Res Commun, vol.477, pp.834-840, 2016. ,
Computational analysis of the extracellular domain of the Ca(2)(+)-sensing receptor: an alternate model for the Ca(2)(+) sensing region, Biochem Biophys Res Commun, vol.459, pp.36-41, 2015. ,
Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata, Proc Natl Acad Sci U S A, vol.75, pp.4329-4333, 1978. ,
Structural basis for lipid modulation of nicotinic acetylcholine receptor function, Brain Res Brain Res Rev, vol.47, pp.71-95, 2004. ,
Cholesterol as a co-solvent and a ligand for membrane proteins, Protein Sci, vol.23, pp.1-22, 2014. ,
Protein sensors for membrane sterols, Cell, vol.124, pp.35-46, 2006. ,
The sterol-sensing domain: multiple families, a unique role, Trends Genet, vol.18, pp.193-201, 2002. ,
Regulation of the mevalonate pathway, Nature, vol.343, pp.425-430, 1990. ,
, Ebola virus entry requires the cholesterol transporter Niemann-Pick C1, vol.477, pp.340-343, 2011.
Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection, Nature, vol.477, pp.344-348, 2011. ,
Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes, Biophys J, vol.108, pp.1459-1469, 2015. ,
Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis, J Biol Chem, vol.286, pp.18002-18012, 2011. ,
Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis, J Biol Chem, vol.292, pp.8729-8737, 2017. ,
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs, J Biol Chem, vol.279, pp.52772-52780, 2004. ,
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein, J Biol Chem, vol.283, pp.1052-1063, 2008. ,
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop, J Biol Chem, vol.283, pp.1064-1075, 2008. ,
3.3 A structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport, Proc Natl Acad Sci, vol.114, pp.9116-9121, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01975196
Structure of human Niemann-Pick C1 protein, Proc Natl Acad Sci, vol.113, pp.8212-8217, 2016. ,
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol, Cell, vol.137, pp.1213-1224, 2009. ,
, Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection, vol.165, pp.1467-1478, 2016.
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol, J Biol Chem, vol.278, pp.52479-52490, 2003. ,
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis, J Biol Chem, vol.292, pp.19959-19973, 2017. ,
Rhodopsin-cholesterol interactions in bovine rod outer segment disk membranes, Biochim Biophys Acta, vol.1285, pp.47-55, 1996. ,
Cholesterol as modulator of receptor function, Biochemistry, vol.36, pp.10959-10974, 1997. ,
Membrane cholesterol oxidation inhibits ligand binding function of hippocampal serotonin(1A) receptors, Biochem Biophys Res Commun, vol.331, pp.422-427, 2005. ,
A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes, Acta Crystallogr F Struct Biol Commun, vol.71, pp.3-18, 2015. ,
Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes, Biochemistry, vol.51, pp.6266-6288, 2012. ,
Membrane cholesterol in the function and organization of Gprotein coupled receptors, Subcell Biochem, vol.51, pp.439-466, 2010. ,
Crystal structures of agonist-bound human cannabinoid receptor CB1, Nature, vol.547, pp.468-471, 2017. ,
Interaction of G protein coupled receptors and cholesterol, Chem Phys Lipids, vol.199, pp.61-73, 2016. ,
Are specific nonannular cholesterol binding sites present in G-protein coupled receptors?, Biochim Biophys Acta, vol.1788, pp.295-302, 2009. ,
Oligomerization at the membrane: potassium channel structure and function, Adv Exp Med Biol, vol.747, pp.122-136, 2012. ,
Cholesterol and ion channels, Subcell Biochem, vol.51, pp.509-549, 2010. ,
Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini, Channels (Austin), vol.7, pp.303-312, 2013. ,
, Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response. Curr Top Membr, vol.80, pp.25-50, 2017.
Where does cholesterol act during activation of the nicotinic acetylcholine receptor?, Biochim Biophys Acta, vol.1370, pp.299-309, 1998. ,
Rosenhouse-Dantsker A: Cholesterol increases the open probability of cardiac KACh currents, Biochim Biophys Acta, vol.1848, pp.2406-2413, 2015. ,
Interaction of Alzheimer's beta-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation, Biochemistry, vol.53, pp.4489-4502, 2014. ,
Mechanism of cholesterol-assisted oligomeric channel formation by a short Alzheimer beta-amyloid peptide, J Neurochem, vol.128, pp.186-195, 2014. ,
Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases, Mol Med, vol.14, pp.451-464, 2008. ,
Amyloid peptides and proteins in review, Rev Physiol Biochem Pharmacol, vol.159, pp.1-77, 2007. ,
Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls, Ann Neurol, vol.73, pp.104-119, 2013. ,
Amyloid ion channels: a common structural link for protein-misfolding disease, Proc Natl Acad Sci, vol.102, pp.10427-10432, 2005. ,
Alzheimer's disease: which type of amyloid-preventing drug agents to employ?, Phys Chem Chem Phys, vol.15, pp.8868-8877, 2013. ,
Common molecular mechanism of amyloid pore formation by Alzheimer's beta-amyloid peptide and alpha-synuclein, Sci Rep, vol.6, p.28781, 2016. ,
Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide, PLoS One, vol.9, p.104751, 2014. ,
The fusogenic tilted peptide (67-78) of alpha-synuclein is a cholesterol binding domain, Biochim Biophys Acta, vol.1808, pp.2343-2351, 2011. ,
The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of viral fusion peptides, Protein Pept Lett, vol.16, pp.718-725, 2009. ,
The ABCG family of membrane-associated transporters: you don't have to be big to be mighty, Br J Pharmacol, vol.164, pp.1767-1779, 2011. ,
Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles, J Biol Chem, vol.282, pp.25123-25130, 2007. ,
Diverse relations between ABC transporters and lipids: An overview, Biochim Biophys Acta, vol.1859, pp.605-618, 2017. ,
A novel family of mammalian transmembrane proteins involved in cholesterol transport, Sci Rep, vol.7, p.7450, 2017. ,
, Membrane Fusion Stalks and Lipid Rafts: A Love-Hate Relationship, vol.112, pp.2475-2478, 2017.
Role of cholesterol in SNARE-mediated trafficking on intracellular membranes, J Cell Sci, vol.128, pp.1071-1081, 2015. ,
Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling, J Physiol, vol.579, pp.413-429, 2007. ,
Cholesterol reduction impairs exocytosis of synaptic vesicles, J Cell Sci, vol.123, pp.595-605, 2010. ,
Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate, J Biol Chem, vol.284, pp.29489-29498, 2009. ,
Cholesterol effects on vesicle pools in chromaffin cells revealed by carbon-fiber microelectrode amperometry, Anal Bioanal Chem, vol.400, pp.2963-2971, 2011. ,
Roles of cholesterol in vesicle fusion and motion, Biophys J, vol.97, pp.1371-1380, 2009. ,
Specific lipids supply critical negative spontaneous curvature--an essential component of native Ca2+-triggered membrane fusion, Biophys J, vol.94, pp.3976-3986, 2008. ,
Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion, J Cell Sci, vol.118, pp.4833-4848, 2005. ,
Pathogens: raft hijackers, Nat Rev Immunol, vol.3, pp.557-568, 2003. ,
HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains, Nat Chem Biol, vol.11, pp.424-431, 2015. ,
Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain, Embo j, vol.16, pp.5501-5508, 1997. ,
HIV-1 assembly, release and maturation, Nat Rev Microbiol, vol.13, pp.484-496, 2015. ,
Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity, Proc Natl Acad Sci, vol.114, pp.7987-7996, 2017. ,
The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol, Science, vol.336, pp.1168-1171, 2012. ,
Mapping out the intricate relationship of the HIV envelope protein and the membrane environment, Biochim Biophys Acta, vol.1859, pp.550-560, 2017. ,
Peptide-induced formation of cholesterol-rich domains, Biochemistry, vol.42, pp.14677-14689, 2003. ,
The tryptophan-rich region of HIV gp41 and the promotion of cholesterol-rich domains, Biochemistry, vol.44, pp.5525-5531, 2005. ,
Large changes in the CRAC segment of gp41 of HIV do not destroy fusion activity if the segment interacts with cholesterol, Biochemistry, vol.47, pp.11869-11876, 2008. ,
Hydrophobic substitutions in the first residue of the CRAC segment of the gp41 protein of HIV, Biochemistry, vol.47, pp.124-130, 2008. ,
CRAC motif peptide of the HIV-1 gp41 protein thins SOPC membranes and interacts with cholesterol, Biochim Biophys Acta, vol.1778, pp.1120-1130, 2008. ,
Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes, Biophys J, vol.113, pp.1301-1310, 2017. ,
Identification of the LWYIK motif located in the human immunodeficiency virus type 1 transmembrane gp41 protein as a distinct determinant for viral infection, J Virol, vol.83, pp.870-883, 2009. ,
, Figure Legends Figure 1. Geometry of the CRAC/cholesterol complex. The motif is oriented in the N-ter (top) to C-ter (bottom) direction. It displays three distinct zones (apolar in blue, aromatic in yellow
, Two cholesterol molecules bound to the human b2 adrenergic receptor (retrieved from PDB file # 3D4S)