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Catalytic subunit exchanges in the cellulosomes produced by Ruminiclostridium cellulolyticum suggest unexpected dynamics and adaptability of their enzymatic composition

Abstract : Cellulosomes are complex nano-machines produced by cellulolytic anaerobic bacteria such as Ruminiclostridium cellulolyticum (formerly known as Clostridium cellulolyticum). Cellulosomes are composed of a scaffoldin protein displaying several cohesin modules on which enzymatic components can bind to through their dockerin module. Even if the cellulosomes have been studied for decades, very little is known about the dynamics of the assembly. We have investigated the ability of some dockerin-bearing enzymes to chase the catalytic subunits already
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Submitted on : Friday, November 13, 2020 - 12:00:35 PM
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Romain Borne, Minh‐uyen Dao Ti, Henri‐pierre Fierobe, Nicolas Vita, Chantal Tardif, et al.. Catalytic subunit exchanges in the cellulosomes produced by Ruminiclostridium cellulolyticum suggest unexpected dynamics and adaptability of their enzymatic composition. FEBS Journal, Wiley, 2019, ⟨10.1111/febs.15155⟩. ⟨hal-02487375⟩

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