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Nutrigenetics of Blood Cholesterol Concentrations: Towards Personalized Nutrition

Abstract : Purpose of the ReviewTo summarize achievements made in the field of nutrigenetics to personalized nutrition. Moreover, the limitations and challenges observed to enable clinical utilization are discussed.Recent FindingsCurrently, with the availability of low-cost genetic testing and new bioinformatics tools, significant developments have occurred to allow issues inherent to the highly complex nature of genetic data to be tackled. Moreover, new statistical methods have uncovered combinatory patterns of SNPs that collectively explain the high interindividual variability in response to dietary interventions. Yet, the application of these results to personalized dietary recommendations is not straightforward.SummaryData from gene-nutrient interaction studies have provided evidence to understand the inter-individual variation differences in blood cholesterol responses. A need exists for guidelines and regulations in order to apply nutrigenetics to personalized nutrition. Moreover, a multisystem approach including genetics, microbiome and environment is needed to achieve possible practical applications.
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Submitted on : Friday, February 21, 2020 - 3:35:53 PM
Last modification on : Thursday, July 14, 2022 - 4:11:53 AM




Itzel Vazquez-Vidal, Charles Desmarchelier, Peter Jones. Nutrigenetics of Blood Cholesterol Concentrations: Towards Personalized Nutrition. Current Cardiology Reports, Current Medicine Group, 2019, 21 (5), ⟨10.1007/s11886-019-1124-x⟩. ⟨hal-02487403⟩



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