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Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses - Process control and optimization by following in situ CO2 sorption and polymer swelling

Abstract : The supercritical impregnation process was used as a green technology for the elaboration of drug delivery intraocular lenses to mitigate the risk of post-operatory endophthalmitis after cataract surgery. Commercially available hydrophobic acrylic (copolymer of benzyl methacrylate and methyl methacrylate) intraocular lenses (IOLs) were impregnated with gatifloxacin, a fourth generation fluoroquinolone drug, using pure supercritical CO 2 (scCO 2) to obtain solvent-free loaded implants. The interaction phenomena involved in the supercritical impregnation were studied by following in situ scCO 2 sorption within the polymer support and the subsequent IOL swelling, and by taking into account drug solubility in the supercritical fluid phase. The drug impregnation yields determined though in-vitro release studies varied between 0.33 and 1.07 ± 0.07 μg•mg −1 IOL in the studied experimental conditions (8 to 25 MPa, 308 to 328 K and 30 to 240 min impregnation duration). An impregnation duration longer or equal to the time required for a complete CO 2 uptake by the polymer as well as a higher pressure or a higher temperature over the crossover pressure delimiting the upper limit of the retrograde solubility zone, led to higher drug impregnation yields.
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https://hal-amu.archives-ouvertes.fr/hal-02513973
Contributor : Yasmine Masmoudi <>
Submitted on : Tuesday, November 24, 2020 - 5:05:24 PM
Last modification on : Wednesday, November 25, 2020 - 9:40:44 AM

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Kanjana Ongkasin, Yasmine Masmoudi, Thierry Tassaing, Gwenaelle Le-Bourdon, Elisabeth Badens. Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses - Process control and optimization by following in situ CO2 sorption and polymer swelling. International Journal of Pharmaceutics, Elsevier, 2020, 581, pp.119247. ⟨10.1016/j.ijpharm.2020.119247⟩. ⟨hal-02513973⟩

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