N–C Axially Chiral Compounds with an ortho -Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2019

N–C Axially Chiral Compounds with an ortho -Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction

Résumé

The fluorine atom is the second smallest atom; nevertheless, the ortho-fluoro group may lead to stable N-aryl atropisomers when the steric demand of the flanking substituents is large enough. 2-Alkyl-3-(2-fluorophenyl)quinazolin-4-ones and 3-(2-fluorophenyl)-4-methylthiazoline-2-thione were found to be the first N-aryl axially chiral compounds bearing an ortho-fluoro group whose enantiomers were isolated at ambient temperature. The reaction of alkyl halides with the anionic species prepared from 2-ethyl-3-(2-fluorophenyl)quinazolin-4-one presenting an N−C axial chirality provided a model reaction for quantitative evaluation of the steric discrimination (slight difference of steric factor) between hydrogen and fluorine atoms. In the case of low steric demand (allylation reaction) no diastereoselectivity was detected, while in the case of high steric demand (isopropylation reaction) the diastereoselectivity became significant.

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Chimie organique
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Dates et versions

hal-02514527 , version 1 (23-03-2020)

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Asumi Iida, Mizuki Matsuoka, Hiroshi Hasegawa, Nicolas Vanthuyne, Daniel Farran, et al.. N–C Axially Chiral Compounds with an ortho -Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction. Journal of Organic Chemistry, 2019, 84 (6), pp.3169-3175. ⟨10.1021/acs.joc.8b03043⟩. ⟨hal-02514527⟩
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