Rational and design of the ROTAS study: a randomized study for the optimal treatment of symptomatic patients with low-gradient severe aortic valve stenosis and preserved left ventricular ejection fraction

Elena Galli (1, 2) , Florent Le Ven (3) , Augustin Coisne (4) , Catherine Sportouch (5) , Thierry Le Tourneau (6) , Anne Bernard (7) , Loïc Bière (8) , Gilbert Habib (9, 10) , Patrizio Lancellotti (11) , Mathieu Lederlin (2, 12) , Christophe Tribouilloy (13, 14) , Emmanuel Oger (15, 16) , Erwan Donal (1, 2)

1 Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes]
2 LTSI - Laboratoire Traitement du Signal et de l'Image
3 DMIP - Brest - Département de Médecine Interne et Pneumologie [Brest]
4 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
5 Clinique du Millénaire - Oc Santé [Montpellier]
6 ITX-lab - Unité de recherche de l'institut du thorax
7 CHU Trousseau [Tours]
8 BNMI - Biologie Neurovasculaire et Mitochondriale Intégrée
9 TIMONE - Hôpital de la Timone [CHU - APHM]
10 MEPHI - Microbes évolution phylogénie et infections
11 Service de cardiologie [Liège]
12 CHU Pontchaillou [Rennes]
13 Service de Cardiologie [Amiens]
14 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
15 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
16 CIC - Centre d'Investigation Clinique [Rennes]

Keywords: Stroke volume; Aortic stenosis; Randomized study; Low gradient

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Elena Galli, Florent Le Ven, Augustin Coisne, Catherine Sportouch, Thierry Le Tourneau, et al.. Rational and design of the ROTAS study: a randomized study for the optimal treatment of symptomatic patients with low-gradient severe aortic valve stenosis and preserved left ventricular ejection fraction. European Heart Journal - Cardiovascular Imaging, 2021, 22 (2), pp.229-235. ⟨10.1093/ehjci/jeaa036⟩. ⟨hal-02517850⟩