Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders

Emmanuel Fenouillet (1) , Giovanna Mottola (1) , Nathalie Kipson (1) , Franck Paganelli (1) , Régis Guieu (1) , Jean Ruf (1)

1 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research

Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of "receptor reserve", also known as "spare receptors". This kind of receptors allow agonists to achieve their maximal effect without occupying all of the relevant cell receptors. In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease or some kinds of neurocardiogenic syncopes. In both cases, the presence of spare receptors appears to be an attempt to overcome a weak interaction between adenosine and its receptors. The identification of adenosine spare receptors in cardiovascular disorders may be helpful for diagnostic purposes.

Mots clés: syncope; adenosine; adenosinergic system; cardiovascular disorders; coronary artery disease; receptor reserve; spare receptor

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Cardiologie et système cardiovasculaire

Emmanuel Fenouillet, Giovanna Mottola, Nathalie Kipson, Franck Paganelli, Régis Guieu, et al.. Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders. International Journal of Molecular Sciences, 2019, 20 (13), pp.5964. ⟨10.3390/ijms20235964⟩. ⟨hal-02555995⟩