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Immunotherapy for cancer in people living with HIV

Abstract : Objective: To report efficacy and tolerance of nivolumab or pembrolizumab, PD-1 inhibitors, in people living with HIV (PLWHIV) and cancer. Design: Series of PLWHIV cancer patients treated with anti-PD1 agents in real-life clinical practice. Methods: From May 2014 to January 2019, 575 HIV-infected patients have been discussed in the French CANCERVIH national multidisciplinary board and included in the network database. Twenty-three patients were treated with immune checkpoint inhibitors in daily practice. We report the demographic characteristics, CD4+ T-cell counts, HIV viral loads, safety and efficacy data of these 23 PLWHIV treated in routine practice with nivolumab or pembrolizumab for nonsmall cell lung cancer (n = 21), melanoma (n = 1) and head and neck cancer (n = 1) retrospectively collected from the database CANCERVIH network. The median CD4+ T-cell count at treatment initiation was 370 cells/μl (IQR: 125–1485). HIV viral load was undetectable in all patients. Results: As of 29 April 2019, with a median follow-up of 10.8 months (2.0–27.7), the median number of injections was 6 (IQR: 4–18). Only two grade 3 adverse reactions were reported (no toxic deaths or immune-related deaths). Among the 23 patients, a partial response was observed in five patients (22%), a stabilization for five (22%) and a progression in 13 (57%). Only one patient experienced a positive HIV viral load, but this occurred following ART interruption. Conclusion: Treatment with PD-1 inhibitors seems to have an efficacy signal and be well tolerated in PLWHIV, including impact on CD4+ lymphocyte count and HIV load, that should be monitored during treatment course (regarding real-life experience).
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https://hal-amu.archives-ouvertes.fr/hal-02591390
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Submitted on : Friday, May 15, 2020 - 3:04:38 PM
Last modification on : Wednesday, August 19, 2020 - 11:19:03 AM

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Jean Philippe Spano, Marianne Veyri, Aurélien Gobert, Amelie Guihot, Philippe Perré, et al.. Immunotherapy for cancer in people living with HIV. AIDS, Lippincott, Williams & Wilkins, 2019, 33 (11), pp.F13-F19. ⟨10.1097/QAD.0000000000002298⟩. ⟨hal-02591390⟩

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