Clinical effectiveness of osteoporosis treatment in older patients: A fracture liaison service-based prospective study

Benedicte Mugnier (1, 2) , Aurélie Daumas (3, 4, 2) , Anne-Laure Couderc (2) , Barbara Mizzi (2) , Thomas González (2) , Anne Amrani (2) , Pierre Lévêque (2) , Brice Aymes (2) , Jean-Noël Argenson (5, 2) , Patrick Villani (6, 2)

1 CIML - Centre d'Immunologie de Marseille - Luminy
2 APHM - Assistance Publique - Hôpitaux de Marseille
3 TIMONE - Hôpital de la Timone [CHU - APHM]
4 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
5 ISM - Institut des Sciences du Mouvement Etienne Jules Marey
6 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale

The clinical efficacy of anti-osteoporotic treatments in old patients is discussed. The aim of this study was to assess if the use of anti-osteoporotic treatments for the secondary prevention of osteoporotic fractures could reduce the risk of refractures in patients over 75 years old in a Fracture Liaison Service. In this population of frail, elderly patients presenting with a recent osteoporotic fracture, we observed that the refracture incidence was similar in the treated group and the untreated group during the first year. However, 30 months after the index fracture, the osteoporosis medication for a year or more reduced the incidence of refractures by 70%.

Mots clés: Fracture liaison service; older people; osteoporotic fracture prevention

Domaines: Sciences du Vivant [q-bio]

Benedicte Mugnier, Aurélie Daumas, Anne-Laure Couderc, Barbara Mizzi, Thomas González, et al.. Clinical effectiveness of osteoporosis treatment in older patients: A fracture liaison service-based prospective study. Journal of Women and Aging, 2019, 31 (6), pp.553-565. ⟨10.1080/08952841.2018.1529473⟩. ⟨hal-02592951⟩