New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients

Loraine Vatin (1, 2) , Joanna Vitte (3) , Thomas Radulesco (4) , Jean-Baptiste Morvan (2) , Jean Del del Grande (5) , Arthur Varoquaux (6) , Stephane Ranque (7) , Jean Gaudart (8) , Patrick Dessi (3, 4, 9) , Carole Cassagne (7) , Justin Michel (4, 2)

1 AMU MED - Aix-Marseille Université - Faculté de médecine
2 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
3 APHM - Assistance Publique - Hôpitaux de Marseille
4 IUSTI - Institut universitaire des systèmes thermiques industriels
5 Laboratoire d'Anatomopathologie [Aix-Marseille]
6 Service d'Imagerie Médicale [Hôpital de la Conception - APHM]
7 IP-TPT - Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques
8 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
9 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé

Allergic fungal sinusitis (AFS) is a subgroup within noninvasive fungal chronic rhinosinusites. Its paraclinical diagnosis is based on a « gold standard »: rhinosinusitis evolving for at least 12 weeks or persisting on CT scan, allergic mucin seen during surgery, identification of Charcot‐Leyden crystals or eosinophils aggregates in pathology, fungal hyphae on direct examination or culture. Our objective was to search for clinical, radiological, biological, immunological and mycological criteria permitting AFS preoperative diagnosis, within a population operated on for CRS.

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie

Loraine Vatin, Joanna Vitte, Thomas Radulesco, Jean-Baptiste Morvan, Jean Del del Grande, et al.. New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients. Clinical Otolaryngology, 2019, 44 (1), pp.91-96. ⟨10.1111/coa.13243⟩. ⟨hal-02611847⟩