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Community-Based Care in the ANRS-IPERGAY Trial: The Challenges of Combination Prevention

Costanza Puppo 1 Xavier Mabire 1 Laurent Cotte 2 Daniela Rojas Castro 3, 4 Bruno Spire 3 Eric Cua 5 Gilles Pialoux 6 Marie Suzan-Monti 3 Armelle Pasquet 7 François Raffi 8 Jean-Michel Molina 9 Marie Préau 1
1 GRePS - Groupe de Recherche en Psychologie Sociale
2 Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL]
3 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
4 Coalition PLUS [Pantin, France]
5 Hôpital l'Archet
6 Service des maladies infectieuses et tropicales [CHU Tenon]
7 Service des Maladies Infectieuses et Tropicales [Hôpital Gustave Dron, Tourcoing]
8 CHU Nantes - Centre hospitalier universitaire de Nantes
9 Service de maladies infectieuses et tropicales [Saint-Louis]
Abstract : ANRS-IPERGAY was a community-based randomized trial investigating the efficacy of sexual activity-based HIV pre-exposure prophylaxis (PrEP) in a population of males and transgender females who had sex with men and were at high risk of HIV infection. We qualitatively analyzed the support provided to participants by community-based health workers (CBHW) throughout the trial's double-blind and open-label extension phases. In particular, we showed that the relationship between participants and CBHW strongly influenced self-managed pill intake. The delicate construction of this relationship, balanced between trust and dependence, played an important role in PrEP adherence. CBHW had to deal with various issues surrounding participants' feelings of empowerment regarding their role in the trial, as well as related tensions between various logics and rationalities. They were essential to participants' continued involvement.
Keywords : community-based care ANRS-IPERGAY PrEP HIV empowerment negotiation France Read More: https://guilfordjournals.com/doi/10.1521/aeap.2019.31.3.259
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-02613517
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Submitted on : Wednesday, May 20, 2020 - 11:01:59 AM
Last modification on : Thursday, December 10, 2020 - 3:11:03 AM

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UNIV-AMU | HCL | UNIV-LYON2 | U1252 | GREPS | UDL | UNIV-PARIS7 | USPC | SORBONNE-UNIVERSITE | UNIV-PARIS

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Costanza Puppo, Xavier Mabire, Laurent Cotte, Daniela Rojas Castro, Bruno Spire, et al.. Community-Based Care in the ANRS-IPERGAY Trial: The Challenges of Combination Prevention. AIDS Education and Prevention, Guilford Press, 2019, 31 (3), pp.259-272. ⟨10.1521/aeap.2019.31.3.259⟩. ⟨hal-02613517⟩

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