Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

Isabelle Poizot-Martin; Eric Rosenthal; Camille Gilbert; Carla Cano; Anne Simon; Caroline Lascoux-Combes; Laurent Alric; Anne Gervais; Didier Neau; Laure Esterle; Dominique Salmon; Philippe Sogni; Linda Wittkop

doi:10.1097/QAI.0000000000001940

Journal articles

Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

Isabelle Poizot-Martin ^{1, 2} Eric Rosenthal ³ Camille Gilbert ⁴ Carla Cano ² Anne Simon ⁵ Caroline Lascoux-Combes ⁶ Laurent Alric ^{7, 8, 9} Anne Gervais ¹⁰ Didier Neau ¹¹ Laure Esterle ⁴ Dominique Salmon ¹² Philippe Sogni ^{13, 14} Linda Wittkop ^{4, 15}

1 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale

2 Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM]

3 Hôpital l'Archet

4 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement

5 Service de médecine interne [CHU Pitié-Salpétrière]

6 Service de maladies infectieuses et tropicales [Saint-Louis]

7 Service de Médecine Interne [Purpan]

8 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement

9 Pôle Digestif [purpan]

10 Services de Maladies Infectieuses et Tropicales [CHU Bichat]

11 Service des maladies infectieuses et tropicales, hôpital Pellegrin

12 Hôpital Hôtel-Dieu [Paris]

13 Département d'hépatologie [CHU Cochin]

14 Lymphopoïèse (UMR_1223 / U1223 / U-Pasteur_4) - Lymphopoïèse

15 Service d'Information médicale [Bordeaux]

Abstract : Background: Hepatitis C virus (HCV) and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction. Setting: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti–smooth muscle actin (aSMA), and anti–liver kidney microsome (aLKM1) antibodies (Ab) in HCV/HIV-coinfected patients during the post–combined antiretroviral therapy era. Methods: A cross-sectional observational study nested in the ANRS CO13 HEPAVIH cohort (NCT number: NCT03324633). We selected patients with both ANA testing and T-cell immunophenotyping determination during the cohort follow-up and collected aLKM1 and aSMA data when available. Logistic regression models were built to determine factors associated with the presence of auto-Ab. Results: Two hundred twenty-three HCV/HIV-coinfected patients fulfilled selection criteria. Prevalence of ANA and aSMA was 43.5% and 23.2%, respectively, and both were detected in 13.3% of patients. Isolated aSMA were detected in 9.9% and aLKM1 in 2 patients. In multivariable analysis, only a low nadir CD4 T-cell count was significantly associated with ANA detection. Conclusions: ANA and aSMA detection remain frequent in HCV/HIV-coinfected patients during the post–combined antiretroviral therapy era, despite fair immune restoration. These results advocate for a close monitoring of ANA before immune checkpoint inhibitor therapy in these patients with greater caution for those with a low nadir CD4 T-cell count.

Keywords : anti–liver kidney microsome antibodies HCV–HIV coinfection non–organ-specific autoantibodies nadir CD4 autoimmune antinuclear anti–smooth muscle actin antibodies

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Santé publique et épidémiologie

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https://hal-amu.archives-ouvertes.fr/hal-02615097
Contributor : Administrateur Hal Amu <>
Submitted on : Friday, May 22, 2020 - 10:12:54 AM
Last modification on : Wednesday, August 19, 2020 - 12:08:18 PM

Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

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Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

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