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Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

Isabelle Poizot-Martin 1, 2 Eric Rosenthal 3 Camille Gilbert 4, 5 Carla Cano 2 Anne Simon 6 Caroline Lascoux-Combes 7 Laurent Alric 8, 9, 10 Anne Gervais 11 Didier Neau 12 Laure Esterle 4, 5 Dominique Salmon 13 Philippe Sogni 14, 15 Linda Wittkop 4, 16, 5
1 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
2 Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM]
3 Hôpital l'Archet
4 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement
5 BPH - Bordeaux population health
6 Service de médecine interne [CHU Pitié-Salpétrière]
7 Service de maladies infectieuses et tropicales [Saint-Louis]
8 Service de Médecine Interne [Purpan]
9 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
10 Pôle Digestif [purpan]
11 Services de Maladies Infectieuses et Tropicales [CHU Bichat]
12 Service des maladies infectieuses et tropicales, hôpital Pellegrin
13 Hôpital Hôtel-Dieu [Paris]
14 Département d'hépatologie [CHU Cochin]
15 Lymphopoïèse (UMR_1223 / U1223 / U-Pasteur_4) - Lymphopoïèse
16 Service d'Information médicale [Bordeaux]
Abstract : Background: Hepatitis C virus (HCV) and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction. Setting: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti–smooth muscle actin (aSMA), and anti–liver kidney microsome (aLKM1) antibodies (Ab) in HCV/HIV-coinfected patients during the post–combined antiretroviral therapy era. Methods: A cross-sectional observational study nested in the ANRS CO13 HEPAVIH cohort (NCT number: NCT03324633). We selected patients with both ANA testing and T-cell immunophenotyping determination during the cohort follow-up and collected aLKM1 and aSMA data when available. Logistic regression models were built to determine factors associated with the presence of auto-Ab. Results: Two hundred twenty-three HCV/HIV-coinfected patients fulfilled selection criteria. Prevalence of ANA and aSMA was 43.5% and 23.2%, respectively, and both were detected in 13.3% of patients. Isolated aSMA were detected in 9.9% and aLKM1 in 2 patients. In multivariable analysis, only a low nadir CD4 T-cell count was significantly associated with ANA detection. Conclusions: ANA and aSMA detection remain frequent in HCV/HIV-coinfected patients during the post–combined antiretroviral therapy era, despite fair immune restoration. These results advocate for a close monitoring of ANA before immune checkpoint inhibitor therapy in these patients with greater caution for those with a low nadir CD4 T-cell count.
Keywords : anti–liver kidney microsome antibodies HCV–HIV coinfection non–organ-specific autoantibodies nadir CD4 autoimmune antinuclear anti–smooth muscle actin antibodies
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-02615097
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Submitted on : Friday, May 22, 2020 - 10:12:54 AM
Last modification on : Tuesday, October 19, 2021 - 10:50:55 PM

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UNIV-AMU | UNIV-TLSE3 | ANRSCO13 | U1252 | CNRS | UP-SCIENCES | PASTEUR | INSERM | SORBONNE-UNIVERSITE | U1219 | PHARMA-DEV | IRD

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Isabelle Poizot-Martin, Eric Rosenthal, Camille Gilbert, Carla Cano, Anne Simon, et al.. Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients. Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2019, 80 (4), pp.461-466. ⟨10.1097/QAI.0000000000001940⟩. ⟨hal-02615097⟩

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