D. Charlesworth and J. H. Willis, The genetics of inbreeding depression, Nat. Rev. Genet, vol.10, pp.783-796, 2009.

A. H. Bittles, M. L. Black, and . Consanguinity, human evolution, and complex diseases, Proc. Natl Acad. Sci, vol.107, pp.1779-1786, 2010.

N. Nakatsuka, The promise of discovering population-specific diseaseassociated genes in South Asia, Nat. Genet, vol.49, pp.1403-1407, 2017.

V. M. Narasimhan, Health and population effects of rare gene knockouts in adult humans with related parents, Science, vol.352, pp.474-477, 2016.

D. Saleheen, Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity, Nature, vol.544, pp.235-239, 2017.

P. K. Joshi, Directional dominance on stature and cognition in diverse human populations, Nature, vol.523, pp.459-462, 2015.

M. Kirin, Genomic runs of homozygosity record population history and consanguinity, PLoS ONE, vol.5, p.13996, 2010.

T. J. Pemberton, Genomic patterns of homozygosity in worldwide human populations, Am. J. Hum. Genet, vol.91, pp.275-292, 2012.

F. C. Ceballos, P. K. Joshi, D. W. Clark, M. Ramsay, and J. F. Wilson, Runs of homozygosity: windows into population history and trait architecture, Nat. Rev. Genet, vol.19, pp.220-234, 2018.

C. Sudlow, UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age, PLoS Med, vol.12, p.1001779, 2015.

R. Mcquillan, Runs of homozygosity in European populations, Am. J. Hum Genet, vol.83, pp.359-372, 2008.

S. Purcell and C. Chang,

R. Mcquillan, Evidence of inbreeding depression on human height, PLoS Genet, vol.8, p.1002655, 2012.

A. Abdellaoui, Association between autozygosity and major depression: stratification due to religious assortment, Behav. Genet, vol.43, pp.455-467, 2013.

J. Bashi, Effects of inbreeding on cognitive performance, Nature, vol.266, pp.440-442, 1977.

K. W. Broman and J. L. Weber, Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain, Am. J. Hum. Genet, vol.65, pp.1493-1500, 1999.

J. Gibson, N. E. Morton, and A. Collins, Extended tracts of homozygosity in outbred human populations, Hum. Mol.Genet, vol.15, pp.789-795, 2006.

T. Lencz, Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia, Proc.Natl. Acad. Sci. USA, vol.104, 2007.

M. C. Keller, P. M. Visscher, and M. E. Goddard, Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data, Genetics, vol.189, pp.237-249, 2011.

J. Yang, S. H. Lee, M. E. Goddard, and P. M. Visscher, GCTA: a tool for genome-wide complex trait analysis, Am. J. Hum. Genet, vol.88, pp.76-82, 2011.

T. Coulson, S. Albon, S. Jon, and J. Pemberton, Microsatellite loci reveal sexdependent responses to inbreeding and outbreeding in Red Deer calves, Evolution, vol.53, pp.1951-1960, 1999.

J. Slate and J. M. Pemberton, Comparing molecular measures for detecting inbreeding depression, J.Evolutionary Biology, vol.15, pp.20-31, 2002.

H. Campbell, Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits, Hum. Mol. Genet, vol.16, pp.233-241, 2007.

A. Abdellaoui, Educational attainment influences levels of homozygosity through migration and assortative mating, PLoS ONE, vol.10, p.118935, 2015.

A. Helgason, S. Pálsson, D. F. Guobjartsson, P. Kristjánsson, and K. Stefánsson, An association between the kinship and fertility of human couples, Science, vol.319, pp.813-816, 2008.

A. H. Bittles, J. C. Grant, S. G. Sullivan, and R. Hussain, Does inbreeding lead to decreased human fertility?, Ann. Hum. Biol, vol.29, pp.111-130, 2002.

G. Alvarez, F. C. Ceballos, and T. M. Berra, Darwin was right: inbreeding depression on male fertility in the Darwin family, Biol. J.Linn.Soc, vol.114, pp.474-483, 2015.

C. Ober, T. Hyslop, and W. W. Hauck, Inbreeding effects on fertility in humans: evidence for reproductive compensation, Am. J. Hum. Genet, vol.64, pp.225-231, 1999.

A. Robert, B. Toupance, M. Tremblay, and E. Heyer, Impact of inbreeding on fertility in a pre-industrial population, Eur. J. Hum. Genet, vol.17, pp.673-681, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00350768

F. R. Day, Physical and neuro-behavioural determinants of reproductive onset and success Europe PMC Funders Group, Nat. Genet, vol.48, pp.617-623, 2016.

J. Huisman, L. E. Kruuk, P. A. Ellis, T. Clutton-brock, and J. M. Pemberton, Inbreeding depression across the lifespan in a wild mammal population, Proc. Natl. Acad. Sci, vol.113, pp.3585-3590, 2016.

C. C. Chang, Second-generation PLINK: rising to the challenge of larger and richer datasets, GigaScience, vol.4, p.7, 2015.

A. Manichaikul, Robust relationship inference in genome-wide association studies, Bioinformatics, vol.26, pp.2867-2873, 2010.

S. Wright, Genetics of populations. Encyclopedia Britannica, vol.10, pp.111-112, 1948.

N. M. Belonogova, G. R. Svishcheva, C. M. Van-duijn, Y. S. Aulchenko, and T. I. Axenovich, Region-based association analysis of human quantitative traits in related individuals, PLoS ONE, vol.8, p.65395, 2013.

J. P. Cook, A. Mahajan, and A. P. Morris, Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes, Eur. J. Hum. Genet, vol.25, pp.240-245, 2017.

D. Buss, The Evolution of Desire: Strategies of Human Mating, vol.15, 2003.

A. Okbay, Genome-wide association study identifies 74 loci associated with educational attainment, Nature, vol.533, pp.539-542, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02017372

W. Viechtbauer, Conducting meta-analyses in R with the metafor Package, J. Stat. Softw, vol.36, pp.1-48, 2010.

E. C. Fieller, Some problems in interval estimation, J. R. Stat. Soc. Ser. B, vol.16, pp.175-185, 1954.

B. Bulik-sullivan, An atlas of genetic correlations across human diseases and traits, Nat. Genet, vol.47, pp.1236-1241, 2015.

L. Yengo, Detection and quantification of inbreeding depression for complex traits from SNP data, Proc. Natl. Acad. Sci, vol.114, pp.8602-8607, 2017.

M. Kardos, P. Nietlisbach, and P. W. Hedrick, How should we compare different genomic estimates of the strength of inbreeding depression?, Proc. Natl. Acad. Sci. USA, vol.115, pp.2492-2493, 2018.

S. Gazal, Inbreeding coefficient estimation with dense SNP data: comparison of strategies and application to HapMap III, Hum. Hered, vol.77, pp.49-62, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-01084018

E. C. Johnson, L. M. Evans, and M. C. Keller, Relationships between estimated autozygosity and complex traits in the UK Biobank, PLoS Genet, vol.14, p.1007556, 2018.

L. F. Keller and D. M. Waller, Inbreeding effects in wild populations, Trends Ecol. Evol, vol.17, pp.230-241, 2002.

T. E. , P. K. , J. F. , D. W. , Y. O. et al.,

A. Doney, Mehdi Hedayati 127 , David A van Heel 147 , Makoto Hirata 148 , Imo Höfer 149, Yi-Jen Hung 151,152 , M Arfan Ikram, vol.84, 0202.

, Andrew A Hicks 39 , Hagit Hochner 142 , Heikki Huikuri 275, Eero Vuoksimaa 237 , Salma M Wakil 132, vol.233, p.61

, Unit of Public Health Solutions, National Institute for Health and Welfare, 565-0871, Japan. 3 Laboratory for Statistical Analysis

, Groningen 9700 RB, The Netherlands. 15 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA. 16 The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount, p.19

U. K. London-w2-1pg, Lausanne 1015, Switzerland. 34 Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. 35 Department of Genetics, Oxford OX3 7BN, UK. 59 Department of Computational Biology and Medical Sciences, vol.9054, p.67, 19104.

U. K. Glasgow-g12-8rz, London EC1M 6BQ, UK. 95 Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Groningen 9713 GZ, the Netherlands. 92 Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, vol.201, p.109, 20133.

, Singapore. 112 Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, vol.117, 14482.

, 122 Institute for Maternal and Child Health -IRCCS Burlo Garofolo, National Health Research Institutes, issue.123, p.124

, Singapore 119228 SG, Singapore. 126 Department of Nutrition, Harvard T.H. Chan School of Public Health, p.131, 17475.

, 139 Medical Genetics, Institute for Maternal and Child Health -IRCCS Burlo Garofolo, Oxford OX3 9DU, UK. 141 Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, vol.101

, Beijing 100730, China. 145 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK. 146 Department of Preventive Medicine

, Bristol BS8 2BY, UK. 165 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, China. 171 Translational Laboratory in Genetic Medicine, Agency for Science, vol.112, p.180, 20132.

, Cambridge CB2 0QQ, UK. 197 Instituto Nacional de Medicina Genómica, Mexico 14610, México. 198 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK. 199 Division of Epidemiology & Community Health, Endocrinology and Metabolism, pp.108-8639, 0201.

, Helsinki 00014, Finland. 207 Hero Heart Institute and Dyanand Medical College and Hospital, The Netherlands. 212 IRCCS Neuromed, Pozzilli (IS) 86077, Italy. 213 Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), vol.75015, p.217

, 226 Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK. 227 RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital, Edinburgh EH4 2XU, Scotland. 237 Institute for Molecular Medicine Finland (FIMM), vol.48109

, Louisiane 70808, USA. 252 Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, 253 Quantinuum Research LLC, p.254

, 10012, USA. 256 Research Institute for Industrial Economics (IFN), vol.102, p.258

N. Imperial-college-healthcare, . Trust, . London, and U. K. London-w12-0hs, 259 Department of Preventive Medicine

, Segrate (Milano) 20090, Italy. 261 Bio4Dreams Scientific Unit, Bio4Dreams SRL, Bio4Dreams -business nursery for life sciences, 20121.

, Institute of Clinical Molecular Biology, p.24105

G. Kiel, Tukholmankatu 8 B, Helsinki 00014, Finland. 264 National Institute for Health and Welfare, Helsinki, Finland. 265 Unit of General Practice, p.269

, USA. 272 Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Stockholm 171 76, Sweden. 273 Department of Paediatrics, Medical Research Center Oulu, vol.84108, 19104.

, Utrecht 3584 CX, Netherlands. 284 Helsinki Collegium for Advanced Studies, Helsinki FI-00014, Finland. 282 Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK. 283 Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, vol.698167, pp.19-311

, 296 Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee, Dundee DD1 9SY, UK. 297 School of Medicine and Public Health, Faculty of Medicine and Health, 298 Division of Obstetrics and Gynaecology, vol.4059, p.301

, The Netherlands. 303 Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine and Health Services, 309 Deutsches Zentrum für Herz-und Kreislauferkrankungen (DZHK), vol.80636, p.311, 1081.

W. Bradford, . Yorkshire, and U. K. 1dp, 312 Cardiovascular Health Research Unit, Division of Cardiology, Singapore 169857 SG, p.315, 17475.

U. K. Bristol-bs8-2pr, 316 Avon Longitudinal Study of Parents and Children (ALSPAC), Bristol BS8, vol.2, p.321, 1011.

U. K. London-w12-0nn, USA. 322 Unit of Genomics and Biomarkers, National Institute for Health and Welfare, Helsinki 00271, Finland. 323 National Heart and Lung Institute, Easter Bush, Midlothian EH25 9RG, Scotland. 326 Program in Medical and Population Genetics, vol.327, 19146.