Is diverting loop ileostomy necessary for completion proctectomy with ileal pouch- anal anastomosis? A multicenter randomized trial of the GETAID Chirurgie group (IDEAL trial): rationale and design (NCT03872271)

Laura Beyer-Berjot (1) , Karine Baumstarck (2) , Sandrine Loubière (3) , Eric Vicaut (4) , Stephane Berdah (5) , Stéphane Benoist (6) , Jérémie Lefêvre (7)

1 CHU Marseille
2 Methodologic and Clinical Research Plateform
3 APHM - Assistance Publique - Hôpitaux de Marseille
4 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
5 Hôpital Nord [CHU - APHM]
6 HALMA - Histoire, Archéologie et Littérature des Mondes Anciens - UMR 8164
7 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

Background: There is no quality evidence of the benefit of defunctioning ileostomy (DI) in ileal pouch-anal anastomoses (IPAAs) performed for inflammatory bowel disease (IBD), but most surgical teams currently resort to DI. In the case of a staged procedure with subtotal colectomy first, completion proctectomy with IPAA is performed for healthy patients, namely, after nutritional support, inflammation reduction and immunosuppressive agent weaning. Therefore, the aim of this trial is to assess the need for systematic DI after completion proctectomy and IPAA for IBD.

Keywords: Pouch-anal anastomosis; Ileostomy; Ulcerative colitis; Staged IPAA; Modified 2-stage IPAA

Domains: Life Sciences [q-bio]; Human health and pathology; Surgery

Laura Beyer-Berjot, Karine Baumstarck, Sandrine Loubière, Eric Vicaut, Stephane Berdah, et al.. Is diverting loop ileostomy necessary for completion proctectomy with ileal pouch- anal anastomosis? A multicenter randomized trial of the GETAID Chirurgie group (IDEAL trial): rationale and design (NCT03872271). BMC Surgery, 2019, 19 (1), ⟨10.1186/s12893-019-0657-7⟩. ⟨hal-02860751⟩