Inequity in access to personalized medicine in France: Evidences from analysis of geo variations in the access to molecular profiling among advanced non-small-cell lung cancer patients: Results from the IFCT Biomarkers France Study
ECM - École Centrale de Marseille : UMR7316 (Pôle de l'étoile - Technopole de Château-Gombert - 38 rue Frédéric Joliot-Curie - 13013 Marseille - France)
Abstract : In this article, we studied geographic variation in the use of personalized genetic testing for advanced non-small cell lung cancer (NSCLC) and we evaluated the relationship between genetic testing rates and local socioeconomic and ecological variables. We used data on all advanced NSCLC patients who had a genetic test between April 2012 and April 2013 in France in the frame of the IFCT Biomarqueurs-France study (n = 15814). We computed four established measures of geographic variation of the sex-adjusted rates of genetic testing utilization at the "dé partment" (the French territory is divided into 94 administrative units called 'dé partements') level. We also performed a spatial regression model to determine the relationship between dé partement-level sex-adjusted rates of genetic testing utilization and economic and ecological variables. Our results are the following: (i) Overall, 46.87% lung cancer admission patients obtained genetic testing for NSCLC; dé partement-level utilization rates varied over 3.2-fold. Measures of geographic variation indicated a relatively high degree of geographic variation. (ii) there was a statistically significant relationship between genetic testing rates and per capita supply of general practitioners, radiotherapists and PLOS ONE
https://hal-amu.archives-ouvertes.fr/hal-02888579
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Submitted on : Friday, July 3, 2020 - 10:17:06 AM Last modification on : Wednesday, December 30, 2020 - 11:08:05 AM Long-term archiving on: : Thursday, September 24, 2020 - 6:52:32 AM
Samuel Kembou Nzale, William Weeks, L’houcine Ouafik, Isabelle Rouquette, Michèle Beau-Faller, et al.. Inequity in access to personalized medicine in France: Evidences from analysis of geo variations in the access to molecular profiling among advanced non-small-cell lung cancer patients: Results from the IFCT Biomarkers France Study. PLoS ONE, Public Library of Science, 2020, 15 (7), pp.e0234387. ⟨10.1371/journal.pone.0234387⟩. ⟨hal-02888579⟩