E. A. Bocchi, R. B. Bestetti, M. I. Scanavacca, C. Neto, E. Issa et al., Chronic chagas heart disease management: from etiology to cardiomyopathy treatment, J Am Coll Cardiol, vol.70, pp.1510-1534, 2017.

J. R. Coura and J. Borges-pereira, Chagas disease. What is known and what should be improved: a systemic review, Rev Soc Bras Med Trop, vol.45, pp.286-96, 2012.

A. P. Barbosa, C. Neto, A. Otaviano, A. P. Rocha, B. F. Bestetti et al., Comparison of outcome between Chagas cardiomyopathy and idiopathic dilated cardiomyopathy, Arq Bras Cardiol, vol.97, pp.517-542, 2011.

R. B. Bestetti and G. Muccillo, Clinical course of Chagas' heart disease: a comparison with dilated cardiomyopathy, Int J Cardiol, vol.60, pp.187-93, 1997.

F. Zicker, P. G. Smith, J. C. Netto, R. M. Oliveira, and E. M. Zicker, Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiopathy, Am J Trop Med Hyg, vol.43, pp.498-505, 1990.

M. Acosta-herrera, M. Strauss, D. Casares-marfil, and J. Martin, Genomic medicine in Chagas disease, Acta Trop, vol.197, p.105062, 2019.

C. Chevillard, J. Nunes, A. F. Frade, R. R. Almeida, R. P. Pandey et al., Disease tolerance and pathogen resistance genes may underlie Trypanosoma cruzi persistence and differential progression to chagas disease cardiomsyopathy, Front Immunol, vol.9, p.2791, 2018.

M. Strauss, M. Acosta-herrera, A. Alcaraz, D. Casares-marfil, P. Bosch-nicolau et al., Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations, PLoS Negl Trop Dis, vol.13, p.7859, 2019.

E. Cunha-neto and C. Chevillard, Chagas disease cardiomyopathy: immunopathology and genetics, Mediators Inflamm, p.683230, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01592694

V. Michailowsky, N. M. Silva, C. D. Rocha, L. Q. Vieira, J. Lannes-vieira et al., Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection, Am J Pathol, vol.159, issue.10, pp.63019-63021, 2001.

A. M. Bilate and E. Cunha-neto, Chagas disease cardiomyopathy: current concepts of an old disease, Rev Inst Med Trop Sao Paulo, vol.50, pp.67-74, 2008.

M. M. Reis, L. Higuchi-mde, L. A. Benvenuti, V. D. Aiello, P. S. Gutierrez et al., An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens, Clin Immunol Immunopathol, vol.83, pp.165-72, 1997.

U. Muller, G. Kohler, H. Mossmann, G. A. Schaub, G. Alber et al., IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18, J Immunol, vol.167, pp.3346-53, 2001.

D. B. Rocha-rodrigues, M. A. Dos-reis, A. Romano, S. A. Pereira, T. Vde et al., In situ expression of regulatory cytokines by heart inflammatory cells in Chagas' disease patients with heart failure, Clin Dev Immunol, p.361730, 2012.

C. Holscher, M. Mohrs, W. J. Dai, G. Kohler, B. Ryffel et al., Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruziinfected interleukin 10-deficient mice, Infect Immun, vol.68, pp.4075-83, 2000.

M. P. Soares, R. Gozzelino, and S. Weis, Tissue damage control in disease tolerance, Trends Immunol, vol.35, pp.483-94, 2014.

T. S. Medina, G. G. Oliveira, M. C. Silva, B. A. David, G. K. Silva et al., Ebi3 prevents Trypanosoma cruzi-induced myocarditis by dampening IFN-gamma-driven inflammation, Front Immunol, vol.8, p.1213, 2017.

F. F. Araujo, J. A. Gomes, M. O. Rocha, S. Williams-blangero, V. M. Pinheiro et al., Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas disease, Front Biosci, vol.12, pp.2797-806, 2007.

E. Cunha-neto and K. J. , Heart-infiltrating and peripheral T cells in the pathogenesis of human Chagas' disease cardiomyopathy, Autoimmunity, vol.34, pp.187-92, 2001.

J. A. Gomes, L. M. Bahia-oliveira, M. O. Rocha, O. A. Martins-filho, G. Gazzinelli et al., Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response, Infect Immun, vol.71, pp.1185-93, 2003.

M. Ribeirao, V. L. Pereira-chioccola, L. Renia, A. F. Filho, A. Schenkman et al., Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase, Parasite Immunol, vol.22, pp.49-53, 2000.

L. C. Abel, L. V. Rizzo, B. Ianni, F. Albuquerque, F. Bacal et al., Chronic Chagas' disease cardiomyopathy patients display an increased IFNgamma response to Trypanosoma cruzi infection, J Autoimmun, vol.17, pp.99-107, 2001.

J. A. Gomes, L. M. Bahia-oliveira, M. O. Rocha, S. C. Busek, M. M. Teixeira et al., Type 1 chemokine receptor expression in Chagas' disease correlates with morbidity in cardiac patients, Infect Immun, vol.73, pp.7960-7966, 2005.

R. C. Ferreira, B. M. Ianni, L. C. Abel, P. Buck, C. Mady et al., Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/"indeterminate" and Chagas disease cardiomyopathy patients, Mem Inst Oswaldo Cruz, vol.98, pp.407-418, 2003.

G. R. Sousa, J. A. Gomes, R. C. Fares, M. P. Damasio, A. T. Chaves et al., Plasma cytokine expression is associated with cardiac morbidity in chagas disease, PLoS ONE, vol.9, p.87082, 2014.

A. Talvani, M. O. Rocha, A. L. Ribeiro, R. Correa-oliveira, and M. M. Teixeira, Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease, J Infect Dis, vol.189, pp.214-234, 2004.

L. G. Nogueira, R. H. Santos, A. I. Fiorelli, E. C. Mairena, L. A. Benvenuti et al., Myocardial gene expression of T-bet, GATA-3, Ror-gammat, FoxP3, and hallmark cytokines in chronic Chagas disease cardiomyopathy: an essentially unopposed TH1-type response, Mediators Inflamm, p.914326, 2014.

M. De-alba-alvarado, P. M. Salazar-schettino, L. Jimenez-alvarez, M. Cabrera-bravo, C. Garcia-sancho et al., Th-17 cytokines are associated with severity of Trypanosoma cruzi chronic infection in pediatric patients from endemic areas of Mexico, Acta Trop, vol.178, pp.134-175, 2018.

L. E. Alvarado-arnez, E. N. Venegas, C. Ober, and E. E. Thompson, Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians, J Allergy Clin Immunol, vol.127, pp.1-3, 2011.

O. Florez, J. Martin, and C. I. Gonzalez, Interleukin 4, interleukin 4 receptoralpha and interleukin 10 gene polymorphisms in Chagas disease, Parasite Immunol, vol.33, pp.506-517, 2011.

G. Zafra, C. Morillo, J. Martin, A. Gonzalez, and C. I. Gonzalez, , vol.3

, ? UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy, Microbes Infect, vol.9, pp.1049-52, 2007.

D. M. Turner, D. M. Williams, D. Sankaran, M. Lazarus, P. J. Sinnott et al., An investigation of polymorphism in the interleukin-10 gene promoter

, Eur J Immunogenet, vol.24, pp.1-8, 1997.

G. C. Costa, M. O. Da-costa-rocha, P. R. Moreira, C. A. Menezes, M. R. Silva et al., Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy, J Infect Dis, vol.199, pp.451-455, 2009.

E. Cunha-neto, V. J. Dzau, P. D. Allen, D. Stamatiou, L. Benvenutti et al., Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy, Am J Pathol, vol.167, issue.10, pp.62976-62984, 2005.

M. T. Jorge, T. A. Macedo, R. S. Janones, D. P. Carizzi, R. A. Heredia et al., Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients, Ann Trop Med Parasitol, vol.97, pp.139-187, 2003.

J. L. Januzzi, Natriuretic peptides, ejection fraction, and prognosis: parsing the phenotypes of heart failure, J Am Coll Cardiol, vol.61, pp.1507-1516, 2013.

D. J. Van-veldhuisen, G. C. Linssen, T. Jaarsma, W. H. Van-gilst, A. W. Hoes et al., B-type natriuretic peptide and prognosis in heart failure patients with preserved and reduced ejection fraction, J Am Coll Cardiol, vol.61, pp.1498-506, 2013.

L. G. Nogueira, R. H. Santos, B. M. Ianni, A. I. Fiorelli, E. C. Mairena et al., Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10, PLoS Negl Trop Dis, vol.6, p.1867, 2012.

S. Holm, A simple sequentially rejective multiple test procedure, Scand J Stat, vol.6, pp.65-70, 1979.

A. Salhi, V. Rodrigues, F. Santoro, H. Dessein, A. Romano et al., Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis, J Immunol, vol.180, p.6139, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01592701

K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume, Interferon-gamma: an overview of signals, mechanisms and functions, J Leukoc Biol, vol.75, pp.163-89, 2004.