Skip to Main content Skip to Navigation
Journal articles

Human Respiratory Syncytial Virus-induced immune signature of infection revealed by transcriptome analysis of clinical pediatric nasopharyngeal swab samples

Abstract : Human Respiratory Syncytial Virus (HRSV) constitutes one the main causes of respiratory infection in neonates and infants worldwide. Transcriptome analysis of clinical samples using high-throughput technologies remains an important tool to better understand virus-host complex interactions in the real-life setting but also to identify new diagnosis/prognosis markers or therapeutics targets. A major challenge when exploiting clinical samples such as nasal swabs, washes or bronchoalveolar lavages is the poor quantity and integrity of nucleic acids. In this study, we applied a tailored transcriptomics workflow to exploit nasal wash samples from children who tested positive for HRSV. Our analysis revealed a characteristic immune signature as a direct reflection of HRSV pathogenesis and highlighted putative biomarkers of interest such as IP-10, TMEM190, MCEMP1 or TIMM23.
Complete list of metadatas

Cited literature [60 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02909729
Contributor : Olivier Terrier <>
Submitted on : Friday, July 31, 2020 - 9:25:00 AM
Last modification on : Wednesday, November 4, 2020 - 3:12:34 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-01-29

Please log in to resquest access to the document

Identifiers

Citation

Claire Nicolas de Lamballerie, Andres Pizzorno, Julia Dubois, Blandine Padey, Thomas Julien, et al.. Human Respiratory Syncytial Virus-induced immune signature of infection revealed by transcriptome analysis of clinical pediatric nasopharyngeal swab samples. Journal of Infectious Diseases, Oxford University Press (OUP), inPress, ⟨10.1093/infdis/jiaa468/5877957⟩. ⟨hal-02909729⟩

Share

Metrics

Record views

119