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A Chemogenetic Tool that Enables Functional Neural Circuit Analysis

Hoai Ngo 1 Mariana Melo 2 Ross Bathgate 1, 2 Sharon Layfield 1 Angela Connelly 2 Jaspreet Bassi 2 Lin Xie 2 Clément Menuet 3 Stuart Mcdougall 1 Ross A.D. Bathgate 2 Andrew Allen 1, 2
1 Howard Florey Institute
2 University of Melbourne
3 INMED - INSERM U1249 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
Abstract : Graphical Abstract Highlights d Oxytocin is replaced in its precursor with the insect peptide allatostatin (Ast) d Viral expression induces activity-dependent, synaptic release of bioactive Ast d Ast is expressed in vagal afferents and Ast receptor in Phox2 NTS neurons d This induces a long-term reduction in baroreceptor sensitivity and bodyweight gain
Keywords : allatostatin chemogenetics viral transduction viscerosensory system baroreceptor sensitivity vagus nucleus of the solitary tract bodyweight
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Hoai Ngo, Mariana Melo, Ross Bathgate, Sharon Layfield, Angela Connelly, et al.. A Chemogenetic Tool that Enables Functional Neural Circuit Analysis. Cell Reports, Elsevier Inc, In press, 32 (11), pp.108139. ⟨10.1016/j.celrep.2020.108139⟩. ⟨hal-02963987⟩

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