Combination of Alcohol and EVOH as a New Embolic Agent: Midterm Tissue and Inflammatory Effects in a Swine Model

Jean-François Hak (1, 2, 3) , Farouk Tradi (1, 2, 3) , Mickael Bobot (3, 4, 5) , Pauline Brige (2, 3) , Paul Habert (1, 2, 3) , Sophie Chopinet (2, 3, 6) , Aurélie Haffner (7) , Gilles Soulez (8) , Benjamin Guillet (3, 5, 9) , Vincent Vidal (1, 2, 3)

1 Département de Radiologie [Hôpital de la Timone - APHM]
2 LIIE - Laboratoire d'Imagerie Interventionnelle Expérimentale
3 CERIMED - Centre Européen de Recherche en Imagerie médicale
4 Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM]
5 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
6 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
7 ACPNP - Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]
8 CHUM - Centre Hospitalier de l'Université de Montréal
9 Service de Radiopharmacie [Hôpital de la Timone- Hôpital Nord - APHM]

Objective. To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18 ®) (75%) and alcohol (25%)-Alco-Squid 18-in a swine model. Materials and Methods. Alco-Squid 18 (75% Squid 18 ® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18 ® (S18 ®) alone. An arteriovenous malformation (AVM) model was created in group 1 (n = 2). Each AVM model was then embolized with AS18 or S18 ® alone with evaluation of a ratio between the volume of embolic agent divided by the volume of the AVM (evaluated by CT). For group 2 (n = 5), each agent was tested on three different kidneys (upper pole kidney artery). Pre-and postinterventional CTs, angiographies, blood alcohol content dosages, and histological studies (3 months postintervention) were performed. Results. AS18 has better distal distribution than S18 ® alone, both in the kidneys (mean capsule-S18 ® distance: 3.9 mm (±0.23) and mean capsule-AS18 distance: 2.3 mm (±0.11) (p = 0.029) and in the AVM model. Histological exploration found a higher rate of tubular necrosis with AS18 compared with S18 ® alone and alcohol alone (3.78 ± 0.44 compared to 2.33 ± 1.22 (p = 0.012) and 1.22 ± 0.67 (p < 0 .0001)). e blood alcohol content was negligible in all cases. Conclusion. AS18 can suggest a better distal sclerotic and embolic character as compared with S18 ® alone without systemic toxicity.

Domaines: Sciences du Vivant [q-bio]; Imagerie; Cardiologie et système cardiovasculaire

Jean-François Hak, Farouk Tradi, Mickael Bobot, Pauline Brige, Paul Habert, et al.. Combination of Alcohol and EVOH as a New Embolic Agent: Midterm Tissue and Inflammatory Effects in a Swine Model. Radiology Research and Practice, 2020, 2020, pp.1-8. ⟨10.1155/2020/8831060⟩. ⟨hal-02984048⟩