6IrsiCaixa (Institut de Recerca de la Sida) (Institut de Recerca del Sida IrsiCaixa, Hospital Germans Trias i Pujol, Ctra. de Canyet, s/n, 08916 Badalona (Barcelona) - Spain)
Abstract : While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. To identify molecular factors associated with TNT function, we performed a transcriptomic analysis in these macrophages, and revealed the upregulation of Siglec-1 receptor. Siglec-1 expression depends on Mtb-induced production of type I interferon (IFN-I). In co-infected non-human primates, Siglec-1 is highly expressed by alveolar macrophages, whose abundance correlates with pathology and activation of IFN-I/STAT1 pathway. Siglec-1 localizes mainly on microtubule-containing TNT that are long and carry HIV-1 cargo. Siglec
https://hal-amu.archives-ouvertes.fr/hal-02995702 Contributor : Anita DUMENILConnect in order to contact the contributor Submitted on : Friday, November 20, 2020 - 6:23:19 PM Last modification on : Wednesday, June 1, 2022 - 4:24:54 AM