Skip to Main content Skip to Navigation
Journal articles

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Abstract : Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-02998769
Contributor : Anita Dumenil <>
Submitted on : Thursday, May 6, 2021 - 4:55:30 PM
Last modification on : Wednesday, May 12, 2021 - 7:59:29 PM

File

s41467-020-18512-7 MB Dental c...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Jan Krivanek, Ruslan Soldatov, Maria Eleni Kastriti, Tatiana Chontorotzea, Anna Nele Herdina, et al.. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-18512-7⟩. ⟨hal-02998769⟩

Share

Metrics

Record views

47

Files downloads

9