Journal articles
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Abstract : The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been implicated in reward seeking. However, the precise molecular and physiological basis of reward-seeking behavior remains unknown. We found that the specific deletion of metabotropic glutamate receptor 5 (mGluR5) in D1-expressing MSNs (D1miRmGluR5 mice) abolishes eCB-mediated long-term depression (LTD) and prevents the expression of drug (cocaine and ethanol), natural reward (saccharin), and brain-stimulation-seeking behavior. In vivo enhancement of 2-arachidonoylglycerol (2-AG) eCB signaling within the NAc core restores both eCB-LTD and reward-seeking behavior in D1miRmGluR5 mice. The data suggest a model where the eCB and glutamatergic systems of the NAc act in concert to mediate reward-seeking responses.
Cited literature [43 references]
https://hal-amu.archives-ouvertes.fr/hal-03007155
Contributor : Christophe Pellegrino Connect in order to contact the contributor
Submitted on : Monday, November 16, 2020 - 3:19:42 PM
Last modification on : Wednesday, October 27, 2021 - 1:52:30 PM
Long-term archiving on: : Wednesday, February 17, 2021 - 7:22:44 PM
Contributor : Christophe Pellegrino Connect in order to contact the contributor
Submitted on : Monday, November 16, 2020 - 3:19:42 PM
Last modification on : Wednesday, October 27, 2021 - 1:52:30 PM
Long-term archiving on: : Wednesday, February 17, 2021 - 7:22:44 PM
File
PIIS2589004220301358.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License