H. R. Noori, A. Cosa-linan, and R. Spanagel, Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis, European Neuropsychopharmacology, vol.26, issue.9, pp.1419-1430, 2016.

M. Novak, B. Halbout, E. C. O'connor, J. Rodriguez-parkitna, T. Su et al., Incentive Learning Underlying Cocaine-Seeking Requires mGluR5 Receptors Located on Dopamine D1 Receptor-Expressing Neurons, Journal of Neuroscience, vol.30, issue.36, pp.11973-11982, 2010.

T. Ohno-shosaku, A. Tanimura, Y. Hashimotodani, and M. Kano, Endocannabinoids and Retrograde Modulation of Synaptic Transmission, The Neuroscientist, vol.18, issue.2, pp.119-132, 2011.

M. F. Olive, Metabotropic Glutamate Receptor Ligands as Potential Therapeutics for Addiction, Current Drug Abuse Reviewse, vol.2, issue.1, pp.83-98, 2009.

B. Pan, W. Wang, P. Zhong, J. L. Blankman, B. F. Cravatt et al., Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice, Journal of Neuroscience, vol.31, issue.38, pp.13420-13430, 2011.

N. Puente, Y. Cui, O. Lassalle, M. Lafourcade, F. Georges et al., Polymodal activation of the endocannabinoid system in the extended amygdala, Nature Neuroscience, vol.14, issue.12, pp.1542-1547, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01160051

D. Robbe, M. Kopf, A. Remaury, J. Bockaert, and O. J. Manzoni, Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens, Proceedings of the National Academy of Sciences, vol.99, issue.12, pp.8384-8388, 2002.

S. J. Russo, D. M. Dietz, D. Dumitriu, J. H. Morrison, R. C. Malenka et al., The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens, Trends in Neurosciences, vol.33, issue.6, pp.267-276, 2010.

C. Sanchis-segura, T. Zghoul, and R. Spanagel, Methods for Behavioural Assessment of Drug-Reinforcement and Addictive Features, Animal Models of Neuropsychiatric Diseases, pp.181-222, 2006.

C. Sanchis-segura and R. Spanagel, Behavioural assessment of drug reinforcement and addictive features in rodents: an overview, Addiction Biology, vol.11, issue.1, pp.2-38, 2006.

C. Sanchis-segura, B. H. Cline, G. Marsicano, B. Lutz, and R. Spanagel, Reduced sensitivity to reward in CB1 knockout mice, Psychopharmacology, vol.176, issue.2, pp.223-232, 2004.

H. D. Schmidt, B. A. Kimmey, A. C. Arreola, and R. C. Pierce, Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking, Addiction Biology, vol.20, issue.2, pp.285-296, 2014.

Y. Shaham, U. Shalev, L. Lu, H. De-wit, and J. Stewart, The reinstatement model of drug relapse: history, methodology and major findings, Psychopharmacology, vol.168, issue.1-2, pp.3-20, 2002.

W. Shen, M. Flajolet, P. Greengard, and D. J. Surmeier, Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity, Science, vol.321, issue.5890, pp.848-851, 2008.

C. M. Sinclair, R. M. Cleva, L. E. Hood, M. F. Olive, and J. T. Gass, mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior, Pharmacology Biochemistry and Behavior, vol.101, issue.3, pp.329-335, 2012.

C. Soares-cunha, B. Coimbra, N. Sousa, and A. J. Rodrigues, Reappraising striatal D1- and D2-neurons in reward and aversion, Neuroscience & Biobehavioral Reviews, vol.68, pp.370-386, 2016.

R. Spanagel, D. Durstewitz, A. Hansson, A. Heinz, F. Kiefer et al., A systems medicine research approach for studying alcohol addiction, Addiction Biology, vol.18, issue.6, pp.883-896, 2013.

T. J. De-vries, Y. Shaham, J. R. Homberg, H. Crombag, K. Schuurman et al., A cannabinoid mechanism in relapse to cocaine seeking, Nature Medicine, vol.7, issue.10, pp.1151-1154, 2001.

X. Wang, K. Moussawi, L. Knackstedt, H. Shen, and P. W. Kalivas, Role of mGluR5 neurotransmission in reinstated cocaine-seeking, Addiction Biology, vol.18, issue.1, pp.40-49, 2012.

L. R. Watterson, P. R. Kufahl, N. E. Nemirovsky, K. Sewalia, L. E. Hood et al., Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator, Psychopharmacology, vol.225, issue.1, pp.151-159, 2012.

Z. X. Xi, J. G. Gilbert, X. Q. Peng, A. C. Pak, X. Li et al., Cannabinoid CB1 Receptor Antagonist AM251 Inhibits Cocaine-Primed Relapse in Rats: Role of Glutamate in the Nucleus Accumbens, Journal of Neuroscience, vol.26, issue.33, pp.8531-8536, 2006.

N. E. Zlebnik and J. F. Cheer, Drug-Induced Alterations of Endocannabinoid-Mediated Plasticity in Brain Reward Regions, The Journal of Neuroscience, vol.36, issue.40, pp.10230-10238, 2016.

, Figure S2: (A) Control group without treatment, (B) mice injected with RN7-IN10 (20 mg/kg). (C) Mice injected with RN7-IN9 (20 mg/kg). Mice injected with RN7-IN8 (20 mg/kg), Sigma Chemical Co, vol.55, p.940

Y. Nawata, K. Kitaichi, and T. Yamamoto, Prevention of drug priming- and cue-induced reinstatement of MDMA-seeking behaviors by the CB1 cannabinoid receptor antagonist AM251, Drug and Alcohol Dependence, vol.160, pp.76-81, 2016.

, Figure 1?source data 1. Final concentrations of internal and external buffer used in each reversal potential experiment after diluting the proteoliposomes.

, Figure 2. FFN102 and DAT dependence of fluorescence transients.

. Deroche, Figure 6?figure supplement 1. The AMPA receptor antagonist DNQX blocks mEPSCs in AgRP neurons., Electrophysiology Whole-cell patch-clamp and extracellular field recordings were made from medium spiny neurons respectively

, Supplemental Information 2: MTT Assay GraphPad Prism Analysis, GraphPad Prism, vol.5, issue.0

, Picrotoxin, Meyler's Side Effects of Drugs, p.761, 2016.

Q. Fallavier and ). France, Figure 2?source data 2. ANOVA analyses and Bonferroni's multiple comparison tests for Figure 2A., LY379268, JZL184 and CP55, 940 were from Tocris, vol.5

, Guanidination Kit Product Development Team, BioTechniques, vol.38, issue.2, p.319, 2005.

M. O. Louis, Figure 4?figure supplement 4. GLUT1 is detectable in the endothelial cells of gliomas and normal brain in wild-type (Gpihbp1+/+) and Gpihbp1?/? mice., They were transcardially perfused with PBS (0.1 M, pH 7.4) and then fixed with 250 ml of 4% formaldehyde, 0.1% glutaraldehyde and 0.2% saturated picric acid in PB (0.1M, pH 7.4)

M. Pbs, Figure 3?figure supplement 1. Purified proteins used in vitro methylation and ubiquitylation assays., Coronal brain vibrosections were cut at 50 µm and collected in 0.1 M PBS (pH, vol.7

H. Date, T. Yokoyama, S. Kanai, Y. Hada, M. Nakao et al., Efficient Registration of Laser-Scanned Point Clouds of Bridges Using Linear Features, International Journal of Automation Technology, vol.12, issue.3, pp.328-338, 2018.

, Synthesis of 2,1-Benzoisoxazole-Containing 1,2,3-Triazoles through Copper-Catalyzed Three-Component Domino Reactions of oBromoacetophenones, Aldehydes, and Sodium Azide, BSA/TBS containing 0.1% sodium azide and 0.004% saponin on a shaker for 1 day at RT

, Figure 4?figure supplement 2. Cytoplasmic localization of Vax1 in RGCs., vol.1, p.100

K. Shaker, TRITERPENOID SAPONIN FROM ZYGOPHYLLUM DUMOSUM, Bulletin of Pharmaceutical Sciences. Assiut, vol.27, issue.1, pp.123-126, 2004.

, Supplementary file 11. Fluorescence stereo microscope filter sets., BSA/TBS overnight at 4ºC and postfixed in 1% glutaraldehyde in TBS for 10 minutes at RT. Following washes in double-distilled water, gold particles were silver-intensified with a HQ Silver kit

, Targeted Strategy to Analyze Antiepileptic Drugs in Human Serum by LC-MS/MS and LC-Ion Mobility-MS, ACN/H 2 O (1:1, v/v)

W. Agilent, ). Germany, A. G. Ctc-analytics, . Zwingen, and ). Switzerland, Figure 1?figure supplement 3. Characterization of HPLC purified F12 by LC-MS.

N. Kobzina, Ag info network needs funds, California Agriculture, vol.62, issue.1, pp.5-5, 2008.

M. A. Deroche, O. Lassalle, L. Castell, E. Valjent, and O. J. Manzoni, Cell-Type- and Endocannabinoid-Specific Synapse Connectivity in the Adult Nucleus Accumbens Core, The Journal of Neuroscience, vol.40, issue.5, pp.1028-1041, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02414387