Interocular suppressive interactions in amblyopia depend on spatial frequency.

Marie Beleyrian (1) , Robert F. Hess (2) , Frederic Matonti (1, 3) , Danièle Denis (1) , Frédéric Chavane (1) , Alexandre Reynaud (2)

1 INT - Institut de Neurosciences de la Timone
2 McGill Vision Research - Department of Ophthalmology and Visual Sciences [Montreal, QC, Canada]
3 Centre Paradis Monticelli [Marseille]

In amblyopia, there is an interocular suppressive imbalance that results in the fixing eye dominating perception. In this study, we aimed to determine whether these suppressive interactions were narrowband and tuned for spatial frequency or broadband and independent of spatial frequency. We measured the contrast sensitivity and masking functions of fifteen amblyopic subjects and seventeen control subjects using the quick Contrast Sensitivity Function (qCSF) approach (Lesmes, Lu, Baek, & Albright, 2010). We first measured the monocular sensitivity functions of each participant and thereafter corrected for it. We then measured masking sensitivity functions for low, mid and high spatial frequency masks, normalized to their visibility. In the control group, we observed that the strength of dichoptic masking is equivalent between the two eyes. It is also tuned such that masking by low spatial frequencies in one eye mainly affects low spatial frequencies in the other eye and masking by high spatial frequencies mainly affects high spatial frequencies. In amblyopes, although the interocular masking is also tuned for spatial frequency, it is not equivalent between the two eyes: the masking effect from the amblyopic to fixing eye is weaker than the other way around. The asymmetry observed in the strength of masking between the two eyes in amblyopia is tuned for spatial frequency. It is not the consequence of the contrast sensitivity deficit of the amblyopic eye nor is it the consequence of abnormally strong masking from the fixing eye. Rather it is due to an abnormally weak masking strength by the amblyopic eye per se.

Mots clés: Spatial frequency; Dichoptic masking; Contrast sensitivity; Amblyopia; qCSF

Domaines: Sciences du Vivant [q-bio]

Marie Beleyrian, Robert F. Hess, Frederic Matonti, Danièle Denis, Frédéric Chavane, et al.. Interocular suppressive interactions in amblyopia depend on spatial frequency.. Vision Research, 2020, 168, pp.18-28. ⟨10.1016/j.visres.2019.11.008⟩. ⟨hal-03023711⟩