Journal articles
Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages
C. Bain
1
D. Gibson
1
N. Steers
2, 3
K. Boufea
1
P. Louwe
1
C. Doherty
1
V. González-Huici
1
R. Gentek
4
M. Magalhaes-Pinto
5
T. Shaw
5, 6
M. Bajenoff
4
C. Bénézech
1
S. Walmsley
1
D. Dockrell
1
P. Saunders
1
N. Batada
1
S. Jenkins
1
M. Magalhaes-Pinto 5
Author
T. Shaw 5, 6
Author
M. Bajenoff 4
Author IdHAL : marc-bajenoff
C. Bénézech 1
Author
S. Jenkins 1
Author
1
University of Edinburgh (Old College South Bridge Edinburgh EH8 9YL - United Kingdom)
2
CUIMC - Columbia University Irving Medical Center (Columbia University Medical Center
622 W 168th St, New York, NY 10032, États-Unis - United States)
3
Columbia University [New York] (Columbia University in the City of New York, 2960 Broadway, New York, NY 10027-6902 - United States)
4
CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France)
- AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7280 (France)
5
Faculty of Biology, Medicine and Health - The Lydia Becker Institute of Immunology and Inflammation [Manchester, UK] (United Kingdom)
- University of Manchester [Manchester] (Oxford Rd, Manchester M13 9PL - United Kingdom)
- Manchester Academic Health Sciences Centre [Manchester, UK] (United Kingdom)
6
Manchester Collaborative Centre for Inflammation Research (United Kingdom)
- University of Manchester [Manchester] (Oxford Rd, Manchester M13 9PL - United Kingdom)
Abstract : Macrophages reside in the body cavities where they maintain serosal homeostasis and provide immune surveillance. Peritoneal macrophages are implicated in the aetiology of pathologies including peritonitis, endometriosis and metastatic cancer thus understanding the factors that govern their behaviour is vital. Using a combination of fate mapping techniques, we have investigated the impact of sex and age on murine peritoneal macrophage differentiation, turnover and function. We demonstrate
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-03025102
Contributor : Anita Dumenil <>
Submitted on : Thursday, December 17, 2020 - 12:28:47 PM
Last modification on : Friday, December 18, 2020 - 6:46:06 PM
Long-term archiving on: : Thursday, March 18, 2021 - 7:10:51 PM
Contributor : Anita Dumenil <>
Submitted on : Thursday, December 17, 2020 - 12:28:47 PM
Last modification on : Friday, December 18, 2020 - 6:46:06 PM
Long-term archiving on: : Thursday, March 18, 2021 - 7:10:51 PM
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- HAL Id : hal-03025102, version 1
- DOI : 10.1126/sciimmunol.abc4466
Citation
C. Bain, D. Gibson, N. Steers, K. Boufea, P. Louwe, et al.. Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages. Science Immunology, American Association for the Advancement of Science, 2020, 5 (48), pp.eabc4466. ⟨10.1126/sciimmunol.abc4466⟩. ⟨hal-03025102⟩
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