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Is CCL18 a potential biomarker of type-2 asthma endotypes?

Abstract : Objective: This exploratory cross-sectional study aimed to evaluate the associations between the chemokine ligand 18 (CCL18) blood level and phenotypic characteristics of asthma.Methods: We evaluated in a sample of 173 asthmatic adult patients from the Cohort of Bronchial obstruction and Asthma (63.4% women; median age 50 +/- interquartile range 27.5 years; median level of CCL18 was 44.1 +/- interquartile range 27.5 ng/mL) the association between CCL18 blood level and allergic features of asthma using a multivariate analysis. Results: We found an association between the log-transformed value of blood CCL18 and age (+0.7% [0.1; 1.3] per 1-year increase, p = 0.033), gender (-25.1% [-42; -3.2] in women, p = 0.029), and nasal polyposis (+38.1% [11.6; 70.9], p = 0.004). No association was observed between CCL18 level and the other main phenotypic characteristics of asthma. Conclusions: Our exploratory study suggests that CCL18 is not an effective biomarker of allergic asthma endotype but may rather be a biomarker of tissue eosinophilia as supported by its association with nasal polyposis.
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https://hal.archives-ouvertes.fr/hal-03046944
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Submitted on : Thursday, July 29, 2021 - 3:02:34 PM
Last modification on : Monday, August 2, 2021 - 11:51:22 AM

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Helen Fouquet, Jonathan Giovannelli, Patricia de Nadaï, Joanne Balsamelli, Patrick Berger, et al.. Is CCL18 a potential biomarker of type-2 asthma endotypes?. Journal of Asthma, Informa Healthcare, In press, pp.1-9. ⟨10.1080/02770903.2020.1861623⟩. ⟨hal-03046944⟩

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