Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept

Min-Chi Ku (1) , María Fernández-Seara (2) , F. Kober (3) , Thoralf Niendorf (1)

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin
2 Radiology Department, Clínica Universidad de Navarra, University of Navarra, Pamplona
3 CRMBM - Centre de résonance magnétique biologique et médicale

The kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI. This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

Mots clés: Magnetic resonance imaging (MRI); Renal; Perfusion; Arterial spin labeling (ASL); Kidney; Mice; Rats

Domaines: Imagerie

Min-Chi Ku, María Fernández-Seara, F. Kober, Thoralf Niendorf. Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept. Preclinical MRI of the kidney, pp.229-239, 2021, ⟨10.1007/978-1-0716-0978-1_13⟩. ⟨hal-03122958⟩