Interest of bacterial pangenome analyses in clinical microbiology - Archive ouverte HAL Access content directly
Journal Articles Microbial Pathogenesis Year : 2020

Interest of bacterial pangenome analyses in clinical microbiology

Abstract

Thanks to the progress and decreasing costs in genome sequencing technologies, more than 250,000 bacterial genomes are currently available in public databases, covering most, if not all, of the major human-associated phylogenetic groups of these microorganisms, pathogenic or not. In addition, for many of them, sequences from several strains of a given species are available, thus enabling to evaluate their genetic diversity and study their evolution. In addition, the significant cost reduction of bacterial whole genome sequencing as well as the rapid increase in the number of available bacterial genomes have prompted the development of pangenomic software tools. The study of bacterial pangenome has many applications in clinical microbiology. It can unveil the pathogenic potential and ability of bacteria to resist antimicrobials as well identify specific sequences and predict antigenic epitopes that allow molecular or serologic assays and vaccines to be designed. Bacterial pangenome constitutes a powerful method for understanding the history of human bacteria and relating these findings to diagnosis in clinical microbiology laboratories in order to optimize patient management.
Fichier principal
Vignette du fichier
1-s2.0-S0882401020306410-main.pdf (641 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03142000 , version 1 (15-02-2021)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

Hussein Anani, Rita Zgheib, Issam Hasni, Didier Raoult, Pierre-Edouard Fournier. Interest of bacterial pangenome analyses in clinical microbiology. Microbial Pathogenesis, 2020, 149, pp.104275. ⟨10.1016/j.micpath.2020.104275⟩. ⟨hal-03142000⟩
43 View
83 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More