Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Biomolecules Année : 2020

Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants

Résumé

Seven naphtho-gamma-pyrones (NγPs), including asperpyrone E, aurasperone A, dianhydroaurasperone C, fonsecin, fonsecinone A, fonsecin B, and ustilaginoidin A, were isolated from Aspergillus tubingensis G131, a non-toxigenic strain. The radical scavenging activity of these NγPs was evaluated using ABTS assay. The Trolox equivalent antioxidant capacity on the seven isolated NγPs ranged from 2.4 to 14.6 µmol L −1. The toxicity and ability of the NγPs to prevent H 2 O 2-mediated cell death were evaluated using normal/not cancerous cells (CHO cells). This cell-based assay showed that NγPs: (1) Are not toxic or weakly toxic towards cells and (2) are able to protect cells from oxidant injuries with an IC 50 on H 2 O 2-mediated cell death ranging from 2.25 to 1800 µmol mL −1. Our data show that A. tubingensis G131 strain is able to produce various NγPs possessing strong antioxidant activities and low toxicities, making this strain a good candidate for antioxidant applications in food and cosmetic industries.
Fichier principal
Vignette du fichier
75 HAL_Biomolecules NGP AAO 2020.pdf (647.6 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03142867 , version 1 (16-02-2021)

Identifiants

Citer

Quentin Carboué, Marc Maresca, Gaëtan Herbette, Sevastianos Roussos, Rayhane Hamrouni, et al.. Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants. Biomolecules, 2020, 10 (1), pp.29. ⟨10.3390/biom10010029⟩. ⟨hal-03142867⟩
83 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More