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Leadless left ventricular endocardial pacing in nonresponders to conventional cardiac resynchronization therapy

Abstract : Background: Endocardial pacing may be beneficial in patients who fail to improve following conventional epicardial cardiac resynchronization therapy (CRT). The potential to pace anywhere inside the left ventricle thus avoiding myocardial scar and targeting the latest activating segments may be particularly important. The WiSE-CRT system (EBR systems, Sunnyvale, CA) reliably produces wireless, endocardial left ventricular (LV) pacing. The purpose of this analysis was to determine whether this system improved symptoms or led to LV remodeling in patients who were nonresponders to conventional CRT. Method: An international, multicenter registry of patients who were nonresponders to conventional CRT and underwent implantation with the WiSE-CRT system was collected. Results: Twenty-two patients were included; 20 patients underwent successful implantation with confirmation of endocardial biventricular pacing and in 2 patients, there was a failure of electrode capture. Eighteen patients proceeded to 6-month follow-up; endocardial pacing resulted in a This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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https://hal-amu.archives-ouvertes.fr/hal-03148900
Contributor : Régis Guieu <>
Submitted on : Monday, February 22, 2021 - 3:54:11 PM
Last modification on : Tuesday, March 23, 2021 - 1:41:24 PM

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Baldeep Sidhu, Bradley Porter, Justin Gould, Benjamin Sieniewicz, Mark Elliott, et al.. Leadless left ventricular endocardial pacing in nonresponders to conventional cardiac resynchronization therapy. Pacing and Clinical Electrophysiology, Wiley, 2020, 43 (9), pp.966-973. ⟨10.1111/pace.13926⟩. ⟨hal-03148900⟩

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