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Early mortality after implantable cardioverter defibrillator: Incidence and associated factors

Abstract : Background: According to guidelines, implantable cardioverter defibrillator (ICD) candidates must have a "reasonable expectation of survival with a good functional status >1 year". Identifying risk for early mortality in ICD candidates could be challenging. We aimed to identify factors associated with a =1-year survival among patients implanted with ICDs. Methods: The DAI-PP program was a multicenter, observational French study that included all patients who received a primary prevention ICD in the 2002-2012 period. Characteristics of patients who survived <= 1 year following the implantation were compared with those who survived N1 year, and predictors of early death determined. Results: Out of the 5539 enrolled patients, survival status at 1 yearwas known for a total of 5,457, and overall 230 (4.2%) survived <= 1 year. Causes of deathwere similar in the two groups. Patientswith <= 1-year survival had lower rates of appropriate (14 vs. 23%; P= 0.004) and inappropriate ICD therapies (2 vs. 7%; P = 0.009) than patients who lived N1 year after ICD implantation. In multivariate analysis, older age, higher NYHA class (>= III), and atrial fibrillation were significantly associatedwith <= 1-year survival. Presence of all 3 risk factors was associatedwith a cumulative 22.63% risk of death within 1 year after implantation. Conclusions: This is the largest study determining the factors predicting earlymortality after ICD implantation. Patients dying within the first year had low ICD therapy rates. A combination of clinical factors could potentially identify patients at risk for early mortality to help improve selection of ICD candidates. (C) 2019 Elsevier B.V. All rights reserved.
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Submitted on : Monday, February 22, 2021 - 5:13:42 PM
Last modification on : Thursday, March 25, 2021 - 3:31:12 AM

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Rodrigue Garcia, Serge Boveda, Pascal Defaye, Nicolas Sadoul, Kumar Narayanan, et al.. Early mortality after implantable cardioverter defibrillator: Incidence and associated factors. International Journal of Cardiology, Elsevier, 2020, 301, pp.114-118. ⟨10.1016/j.ijcard.2019.09.033⟩. ⟨hal-03149047⟩

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