Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

Raphael Godefroy (1, 2, 3, 4, 5) , Audrey Giraud-Gatineau (2, 3, 4) , Marie-Therese Jimeno (6) , Sophie Edouard (3, 2, 4) , Line Meddeb (2, 3, 4) , Christine Zandotti (2, 7, 8) , Herve Chaudet (2, 3, 4) , Philippe Colson (5, 2) , Didier Raoult (5, 2) , Nadim Cassir (2, 5)

1 AMU SMPM MED - Aix-Marseille Université - École de médecine
2 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
3 VITROME - Vecteurs - Infections tropicales et méditerranéennes
4 APHM - Assistance Publique - Hôpitaux de Marseille
5 MEPHI - Microbes évolution phylogénie et infections
6 Service de l'Information Médicale [Marseille]
7 EPV - Emergence des Pathologies Virales
8 TIMONE - Hôpital de la Timone [CHU - APHM]

Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV-bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV-bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30-6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed.

Mots clés: bacterial coinfection; mortality; pneumonia; respiratory syncytial virus

Domaines: Sciences du Vivant [q-bio]

Raphael Godefroy, Audrey Giraud-Gatineau, Marie-Therese Jimeno, Sophie Edouard, Line Meddeb, et al.. Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults. Open Forum Infectious Diseases, 2020, 7 (12), ⟨10.1093/ofid/ofaa546⟩. ⟨hal-03149230⟩