Diagnostic tools for bacterial infections in travellers: Current and future options

Sophie Alexandra Baron (1, 2) , Carole Eldin (3, 1) , Frederique Gouriet (1, 2) , Gregory Dubourg (2, 1)

1 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
2 MEPHI - Microbes évolution phylogénie et infections
3 VITROME - Vecteurs - Infections tropicales et méditerranéennes

International travel has increased dramatically over the past 50 years, and travel destinations have diversified. Although physicians are more familiar with the panel of aetiological agents responsible for illnesses of returning travellers, thanks to regular epidemiological studies, the spectrum of pathogens potentially encountered in various travel destinations is nevertheless increasing. In addition, the wide array of approaches currently available and addressed in this paper could render the procedures for microbiological analyses increasingly complex. As the time to result is crucial to adequately manage patients, modern approaches have been developed to shorten diagnosis delays. The syndromic approach, which consists of simultaneously testing a wide panel of microorganisms, substantially increases the diagnostic yield with significant time savings, particularly when coupled with point-of-care laboratories. The tools commonly used for this purpose are immunochromatographic tests, mainly targeting bacterial antigens, and multiplex real-time PCR. The emergence of next-generation sequencing technologies, which enable random amplification of genetic material of any microbe present in a clinical specimen, provides further exciting perspectives in the diagnosis of infectious diseases.

Domaines: Sciences du Vivant [q-bio]

Sophie Alexandra Baron, Carole Eldin, Frederique Gouriet, Gregory Dubourg. Diagnostic tools for bacterial infections in travellers: Current and future options. TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2020, 37, ⟨10.1016/j.tmaid.2020.101856⟩. ⟨hal-03149710⟩