Campylobacter jejuni infection associated with miscarriage, a case report and literature review

Fanny Mariette (1) , Sophie Amrane (2, 1) , Cecile Couteau (3) , Jean-Christophe J.-C. Lagier (2, 1) , Carole Eldin (4, 1, 5)

1 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
2 MEPHI - Microbes évolution phylogénie et infections
3 APHM - Assistance Publique - Hôpitaux de Marseille
4 VITROME - Vecteurs - Infections tropicales et méditerranéennes
5 AMU - Aix Marseille Université

Campylobacter jejuni is recognized as a cause of miscarriage in animals, but rarely in humans. We describe here a case of spontaneous miscarriage at 12 weeks of gestation associated with Campylobacter jejuni bacteremia following digestive disorders. The patient was treated with azithromycin with good clinical evolution and underwent uterine aspiration during hospitalization. In our review of the literature, we found only 12 other miscarriages due to C. jejuni infections. Clinicians should consider this cause of miscarriage in febrile pregnant women, as the bacterium is resistant to many beta-lactam antibiotics, and macrolides are the first-line treatment.

Domaines: Sciences du Vivant [q-bio]

Fanny Mariette, Sophie Amrane, Cecile Couteau, Jean-Christophe J.-C. Lagier, Carole Eldin. Campylobacter jejuni infection associated with miscarriage, a case report and literature review. Journal of Reproductive Immunology, 2020, 141, ⟨10.1016/j.jri.2020.103153⟩. ⟨hal-03149720⟩