Discordant courses of COVID‐19 in a cohabiting couple of lung transplant recipients

Nadine Desmazes‐dufeu (1) , Bérengère Coltey (1) , Lyria Amari (1) , Marion Gouitaa (2) , Camille Touzery (1) , Martine Reynaud‐gaubert (1, 3) , Pascal Chanez (2) , Nadim Cassir (3, 4)

1 APHM - Assistance Publique - Hôpitaux de Marseille
2 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
3 MEPHI - Microbes évolution phylogénie et infections
4 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection

COVID-19 is a novel infectious disease caused by SARS-CoV-2 that emerged in late 2019 and which is now a pandemic. Solid organ transplant recipients are perceived to be at increased risk of severe COVID-19 due to their chronic use of immunosuppressive drugs (ISDs) and to their associated conditions. Scarce data are available on the optimized management of ISDs in these patients and on its impact on presentation, clinical course, viral shedding, and outcome. We report here two cases of COVID-19 in a cohabiting couple of lung transplant recipients for cystic fibrosis, who had different ISDs management and who developed discordant courses of their disease. Our findings suggest that the degree of their immunosuppression might be a reason for their different course and that ISDs might prove partially protective.

Mots clés: COVID-19; cystic fibrosis; immunosuppression; lung transplant; SARS-CoV-2; viral pneumonia

Domaines: Bactériologie; Virologie; Parasitologie; Cardiologie et système cardiovasculaire; Maladies émergentes; Maladies infectieuses

Nadine Desmazes‐dufeu, Bérengère Coltey, Lyria Amari, Marion Gouitaa, Camille Touzery, et al.. Discordant courses of COVID‐19 in a cohabiting couple of lung transplant recipients. Transplant Infectious Disease, 2021, ⟨10.1111/tid.13410⟩. ⟨hal-03150308⟩