Skip to Main content Skip to Navigation
New interface
Journal articles

Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?

Abstract : Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limitations related to the clinical relevance of studies on the exercise recommendations in individuals with stroke are first discussed. Then, the relevance of HIIT in improving neurotrophic factors expression, neurogenesis and synaptic plasticity is debated in both stroke and healthy individuals (humans and rodents). Moreover, HIIT may have a preventive role on stroke severity, as found in rodents. The potential role of HIIT in stroke rehabilitation is reinforced by findings showing its powerful neurogenic effect that might potentiate cognitive benefits induced by cognitive tasks. In addition, the clinical role of neuroplasticity observed in each hemisphere needs to be clarified by coupling more frequently to cellular/molecular measurements and behavioral testing.
Document type :
Journal articles
Complete list of metadata
Contributor : Christophe pellegrino Connect in order to contact the contributor
Submitted on : Friday, March 12, 2021 - 7:50:31 AM
Last modification on : Tuesday, May 3, 2022 - 6:26:03 PM
Long-term archiving on: : Sunday, June 13, 2021 - 6:15:27 PM


hugues et al 2021.pdf
Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License


  • HAL Id : hal-03167340, version 1



Nicolas Hugues, Christophe Pellegrino, Claudio Rivera, Eric Berton, Caroline Pin-Barre, et al.. Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?. International Journal of Molecular Sciences, In press, 22. ⟨hal-03167340⟩



Record views


Files downloads