High resolution small‐scale inorganic scintillator detector: HDR brachytherapy application

Sree Bash Chandra Debnath (1, 2) , Marjorie Ferre (3) , Didier Tonneau (1, 2) , Carole Fauquet (1, 2) , Agnes Tallet (3) , Anthony Goncalves (3, 1, 4) , Julien Darreon (3)

1 AMU - Aix Marseille Université
2 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille
3 Département de Radiothérapie [Institut Paoli-Calmettes, Marseille]
4 CRCM - Centre de Recherche en Cancérologie de Marseille

Purpose: Brachytherapy (BT) deals with high gradient internal dose irradiation made up of a complex system where the source is placed nearby the tumor to destroy cancerous cells. A primary concern of clinical safety in BT is quality assurance to ensure the best matches between the delivered and prescribed doses targeting small volume tumors and sparing surrounding healthy tissues. Hence, the purpose of this study is to evaluate the performance of a point size inorganic scintillator detector (ISD) in terms of high dose rate brachytherapy (HDR-BT) treatment. total signal in all the irradiations. Excellent symmetrical behavior of the dose rate regarding source position was observed at different radiation planes. Finally, a comparison with TG-43 reference dataset shows that corrected measurements agreed with simulation data within 1.2% and 1.3%, and valid for the source-to-detector distance greater than 0.25 cm. Conclusion: The proposed ISD in this study anticipated that the system could be promoted to validate with further clinical investigations. It allows an appropriate dose verification with dwelltime estimation during source tracking and suitable dose measurement with a high spatial resolution both nearby (high dose gradient) and far (low dose gradient) from the source position.

Mots clés: Inorganic scintillator detector; brachytherapy; In-vivo dosimetry; Dwell times; 192 Ir

Domaines: Cancer; Physique des Hautes Energies - Expérience [hep-ex]; Matériaux; Traitement du signal et de l'image [eess.SP]

Sree Bash Chandra Debnath, Marjorie Ferre, Didier Tonneau, Carole Fauquet, Agnes Tallet, et al.. High resolution small‐scale inorganic scintillator detector: HDR brachytherapy application. Medical Physics, 2021, ⟨10.1002/mp.14727⟩. ⟨hal-03169741⟩