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Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Christophe Guervilly 1 Stéphane Burtey 2, 3 Florence Sabatier 2, 4 Raphaël Cauchois 2, 5 Guillaume Lano 2 Evelyne Abdili 4 Florence Daviet 4 Laurent Arnaud 4 Philippe Brunet 2 Sami Hraiech 1 Noémie Jourde-Chiche 2 Marie Koubi 4 Romaric Lacroix 2 Léa Pietri 4 Yaël Berda 4 Thomas Robert 4, 2 Clara Degioanni 4 Mélanie Velier 2, 4 Laurent Papazian 1, 6 Gilles Kaplanski 2 Francoise Dignat-George 2, 4
1 Hôpital Nord [CHU - APHM]
2 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
3 Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM]
4 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
5 Laboratoire d'Immunologie [Hôpital de la Conception - APHM]
6 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
Abstract : Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.
Keywords : circulating endothelial cells COVID-19 endothelial injury
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-03171102
Contributor : Annick Prémilleux <>
Submitted on : Tuesday, March 16, 2021 - 4:56:49 PM
Last modification on : Tuesday, March 23, 2021 - 10:10:08 AM

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Distributed under a Creative Commons Attribution 4.0 International License

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UNIV-AMU | CNRS | INRAE | VETAGRO-TIMG-IMAG | INSERM

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Christophe Guervilly, Stéphane Burtey, Florence Sabatier, Raphaël Cauchois, Guillaume Lano, et al.. Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19. Journal of Infectious Diseases, Oxford University Press (OUP), 2020, 222 (11), pp.1789-1793. ⟨10.1093/infdis/jiaa528⟩. ⟨hal-03171102⟩

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