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Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Abstract : Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.
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https://hal-amu.archives-ouvertes.fr/hal-03171102
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Submitted on : Tuesday, March 16, 2021 - 4:56:49 PM
Last modification on : Wednesday, October 27, 2021 - 6:07:47 AM
Long-term archiving on: : Thursday, June 17, 2021 - 7:54:31 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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Christophe Guervilly, Stéphane Burtey, Florence Sabatier, Raphaël Cauchois, Guillaume Lano, et al.. Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19. Journal of Infectious Diseases, Oxford University Press (OUP), 2020, 222 (11), pp.1789-1793. ⟨10.1093/infdis/jiaa528⟩. ⟨hal-03171102⟩

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