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A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles

Abstract : The archetypal tris(benzyltriazolemethyl)amine (TBTA) ligand was equipped with a bowl-shaped cap in the cage Hm-TBTA. Hm-TBTA accelerates CuAAC reactions without suffering from product inhibition. Furthermore, this shielded ligand efficiently protects the copper center from deactivation by the CuI–chelator glutathione, opening the way to novel approaches for efficient CuAAC reactions in complex media.
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https://hal.archives-ouvertes.fr/hal-03175776
Contributor : Cedric Colomban Connect in order to contact the contributor
Submitted on : Friday, December 3, 2021 - 11:55:10 AM
Last modification on : Tuesday, January 4, 2022 - 6:07:25 AM

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Gege Qiu, Paola Nava, Alexandre Martinez, Cédric Colomban. A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles. Chemical Communications, Royal Society of Chemistry, 2021, 57 (18), pp.2281-2284. ⟨10.1039/D0CC08005E⟩. ⟨hal-03175776⟩

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