Sera From Patients With Minimal Change Disease Increase Endothelial Permeability to Sodium

Florence Daviet (1, 2) , Muriel Blin (1) , Karim Fallague (1) , Richard Bachelier (1) , Manon Laforêt (1, 2) , Manon Carré (3) , Stéphane Poitevin (1) , Francoise Dignat-George (1, 4) , Marcel Blot-Chabaud (1) , Nathalie Bardin (1) , Stéphane Burtey (1, 2) , Noémie Jourde-Chiche (1, 2) , Aurélie Leroyer (1)

1 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
2 Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM]
3 AMU - Aix Marseille Université
4 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]

E dema is the main symptom of nephrotic syndrome associated to minimal change disease (MCD). Besides the increase in glomerular permeability, possibly induced by a circulating permeability factor, 1 an increase in systemic vascular permeability could participate in the constitution of edema. This study was conducted to evaluate the permeability of endothelial cells (EC) exposed to serum from nephrotic patients with MCD, to low-or high-molecularweight molecules, by trans-or paracellular transport.

Keywords: Agriculture; Alimentation; Marseille; France

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Human health and pathology; Urology and Nephrology

Florence Daviet, Muriel Blin, Karim Fallague, Richard Bachelier, Manon Laforêt, et al.. Sera From Patients With Minimal Change Disease Increase Endothelial Permeability to Sodium. Kidney International Reports, 2020, 5 (7), pp.1071-1075. ⟨10.1016/j.ekir.2020.04.010⟩. ⟨hal-03176703⟩