Azaphosphatranes Catalyzed Strecker Reaction in the Presence of Water

Jian Yang (1) , Anne-Doriane Manick (1) , Chunyang Li (1) , Xavier Bugaut (1) , Bastien Chatelet (1) , Véronique Dufaud (2) , Damien Hérault (1) , Alexandre Martinez (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 C2P2 - Laboratoire de Chimie, Catalyse, Polymères et Procédés, R 5265

Azaphosphatranes were found to act as efficient organocatalysts in the presence of water for the cyanation of differently substituted imines. A relatively safer source of cyanide, trimethylsilyl cyanide (TMSCN), was used, and excellent yields could be obtained with only 0.05 mol % of catalyst. The influence of acidity of azaphosphatranes on catalytic activity as well as the role of azaphosphatranes in the mechanism of the reaction were also investigated.

Domaines: Chimie

Jian Yang, Anne-Doriane Manick, Chunyang Li, Xavier Bugaut, Bastien Chatelet, et al.. Azaphosphatranes Catalyzed Strecker Reaction in the Presence of Water. ChemistrySelect, 2020, 5 (46), pp.14764-14767. ⟨10.1002/slct.202003602⟩. ⟨hal-03180316⟩