Elevated expression of endogenous glial cell line‐derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus

Pepin Marshall (1) , Daniel R Garton (2) , Tomi Taira (3, 1) , Vootele Võikar (1) , Carolina Vilenius (1) , Natalia Kulesskaya (1) , Claudio Rivera (1, 4) , Jaan‐olle Andressoo (5, 6)

1 NC - HiLIFE - Neuroscience Center
2 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
3 Department of Veterinary Biosciences [Helsinki]
4 INMED - INSERM U1249 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
5 Karolinska Institutet [Stockholm]
6 HiLIFE - Helsinki Institute of Life Science

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Mots clés: dopamine receptor 1; D5; dopamine receptor 5; DA; dopamine; DAergic; dopaminergic; DAT; dopamine transporter; DG; dentate gyrus; DMSO; dimethylsulfoxide; DOPAC; 3; 4-dihydroxyphenylacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N; N; N′; N′-tetraacetic acid; GABAA; GABA receptor type A; GABA; γ-aminobutyric acid; GDNF; glial cell line-derived neurotrophic factor; Gdnf wt/hyper; Gdnf wild-type / hypermorphic heterozygote; Gdnf wt/wt; Gdnf wild-type / wild-type; GFRα1; GDNF family receptor alpha 1; GFRα2; GDNF family receptor alpha 2; GTP; guanosine triphosphate; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IBM; International Business Machines; IT; initial training; mIPSC; minitature inhibitory post-synaptic current; mV; millivolt; N-syndecan; 3N-terminal syndecan 3; pA; picoampere; PBS; phosphate-buffered saline; PP; posteriorparietal cortex; PT; probe trials; PTZ; pentylenetetrazole; PV+; parvalbumin-positive; PV; parvalbumin; RET; rearranged during transfection; RSP; retrosplenial cortex; RT; reversal training; S1B; primary somatosensory cortex; barrer; S1T; trunk; SD; standard deviation; SEM; standard error of the mean; sIPSC; spontaneous inhibitory post-synaptic current; SPSS; Statistics Package for Social Scientists; SS; somatosensory cortex; TBSTD; tris buffered saline with 0.1% tween and 5% DMSO; WM; water maze; WRJ; wild running and jumping; ANOVA; analysis of variance; ATP; adenosine triphosphate; BSA; bovine serum albumin; CA1; cornu ammonis 1; CA3; cornu ammonis 3; CTX; cortex; D1

Domaines: Neurosciences [q-bio.NC]

Pepin Marshall, Daniel R Garton, Tomi Taira, Vootele Võikar, Carolina Vilenius, et al.. Elevated expression of endogenous glial cell line‐derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus. European Journal of Neuroscience, 2021, ⟨10.1111/ejn.15126⟩. ⟨hal-03190538⟩