Asymmetric Organocatalytic Tandem/Domino Reactions Towards Access to Bioactive Products

Hélène Pellissier (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

Tandem and domino reactions constitute economic methodologies to prepare complex molecules starting from simple materials. Especially, combining these powerful procedures to asymmetric catalysis allows direct access to many elaborated chiral products, including important key intermediates in total syntheses of important biologically active compounds. A range of various types of chiral organocatalysts have already been successfully applied to such syntheses. This review presents major developments in the total synthesis of bioactive products based on the use of enantioselective organocatalytic domino/tandem reactions as key steps. It is divided into three parts, dealing successively with syntheses based on organocatalytic asymmetric Michael-initiated domino reactions as key steps; aldol-initiated domino/tandem reactions and other domino reactions.

Mots clés: Total synthesis; bioactive products; enantioselective domino/tandem reactions; organocatalysis; asymmetric catalysis; chirality

Domaines: Chimie

Hélène Pellissier. Asymmetric Organocatalytic Tandem/Domino Reactions Towards Access to Bioactive Products. Current Organic Chemistry, 2021, 25 (13), pp.1457-1471. ⟨10.2174/1385272825666210208142427⟩. ⟨hal-03205965⟩