HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells

Abstract : Abstract Malaria begins when Plasmodium-infected Anopheles mosquitoes take a blood meal on a vertebrate. During the initial probing process, mosquitoes inject saliva and sporozoites into the host skin. Components of mosquito saliva have the potential to influence sporozoite functionality. Sporozoite-associated mosquito saliva protein 1 (SAMSP1; AGAP013726) was among several proteins identified when sporozoites were isolated from saliva, suggesting it may have an effect on Plasmodium. Recombinant SAMSP1 enhanced sporozoite gliding and cell traversal activity in vitro. Moreover, SAMSP1 decreased neutrophil chemotaxis in vivo and in vitro, thereby also exerting an influence on the host environment in which the sporozoites reside. Active or passive immunization of mice with SAMSP1 or SAMSP1 antiserum diminished the initial Plasmodium burden after infection. Passive immunization of mice with SAMSP1 antiserum also added to the protective effect of a circumsporozoite protein monoclonal antibody. SAMSP1 is, therefore, a mosquito saliva protein that can influence sporozoite infectivity in the vertebrate host.
Complete list of metadata

Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Wednesday, April 28, 2021 - 4:26:15 PM
Last modification on : Wednesday, November 3, 2021 - 5:50:26 AM

Links full text




Yu-Min Chuang, Tolulope Agunbiade, Xu-Dong Tang, Marianna Freudzon, Lionel Almeras, et al.. The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells. Journal of Infectious Diseases, Oxford University Press (OUP), 2020, ⟨10.1093/infdis/jiaa759⟩. ⟨hal-03211362⟩



Record views