Reduced peroxisomal import triggers peroxisomal retrograde signaling

Elisabeth Rackles (1) , Michael Witting (2, 3) , Ignasi Forné (1) , Xing Zhang (4) , Judith Zacherl (5) , Simon Schrott (1) , Christian Fischer (1) , Jonathan J Ewbank (4, 6) , Christof Osman (1) , Axel Imhof (1) , Stéphane G Rolland (1, 7)

1 LMU - Ludwig-Maximilians-Universität München
2 BGC - Research Unit Analytical BioGeoChemistry
3 TUM School of Life Sciences Weihenstephan
4 CIML - Centre d'Immunologie de Marseille - Luminy
5 LMU - Ludwig Maximilian University [Munich]
6 TCLS - Turing Centre for Living Systems [Marseille]
7 Institute for Basic Science (IBS) - Ulsan

Highlights d Peroxisomal import stress induces peroxisomal retrograde signaling (PRS) d PRS requires the transcription factors NHR-49/PPARa and MDT-15/MED15 d PRS target genes act in peroxisome quality control, lipid metabolism, and immunity

Keywords: C. elegans; peroxisomal retrograde signaling; peroxisomal β-oxidation; peroxisomal catalase; peroxisomal Lon protease; nhr-49; mdt-15; C. elegans immunity

Domains: Life Sciences [q-bio]

Elisabeth Rackles, Michael Witting, Ignasi Forné, Xing Zhang, Judith Zacherl, et al.. Reduced peroxisomal import triggers peroxisomal retrograde signaling. Cell Reports, 2021, 34, ⟨10.1016/j.celrep.2020.108653⟩. ⟨hal-03223208⟩