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Complement cascade in severe forms of COVID-19: Recent advances in therapy

Abstract : The complement system is an essential component of the innate immune system. The three complement pathways (classical, lectin, alternative) are directly or indirectly activated by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). In the most severe forms of COVID-19, overactivation of the complement system may contribute to the cytokine storm, endothelial inflammation (endotheliitis) and thrombosis. No antiviral drug has yet been shown to be effective in COVID-19. Therefore, immunotherapies represent a promising therapeutic in the immunopathological phase (following the viral phase) of the disease. Complement blockade, mostly C5a-C5aR axis blockade, may prevent acute respiratory distress syndrome (ARDS) from worsening or progression to death. Clinical trials are underway.
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Contributor : Julien Caugant <>
Submitted on : Friday, May 14, 2021 - 1:31:07 PM
Last modification on : Tuesday, May 25, 2021 - 5:46:00 PM


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Nassima Chouaki Benmansour, Julien Carvelli, Eric Vivier. Complement cascade in severe forms of COVID-19: Recent advances in therapy. European Journal of Immunology, Wiley-VCH Verlag, 2021, pp.1-8. ⟨10.1002/eji.202048959⟩. ⟨hal-03226299⟩



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