Fat Grafting for Treatment of Facial Scleroderma

Aurélie Daumas (1) , Jeremy Magalon (1) , Flore Delaunay , Maxime Abellan , Cécile Philandrianos , Florence Sabatier (1) , Brigitte Granel (1) , Guy Magalon

1 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research

Reparative, angiogenic, and immunomodulatory properties have been attributed to the cells in the adipose tissue-derived stromal vascular fraction. Because of these characteristics, in the last decade, fat grafting for treatment of autoimmune diseases has grown. This article focuses on systemic sclerosis, a rare autoimmune disease characterized by skin fibrosis and microvascular damage. Lesions of the face are almost always present; however, current therapy is insufficient and patients have considerable disability and social discomfort. This article presents our approach to using fat grafting in the face as an innovative and promising therapy for patients with systemic sclerosis.

Keywords: Systemic sclerosis; Cell therapy; Microfat injection; Nanofat; Platelet-rich plasma; Stromal vascular fraction; Fat grafting; Adipose tissue; PLATELET-RICH PLASMA; SYSTEMIC-SCLEROSIS; ADIPOSE-TISSUE; SURVIVAL; MANIFESTATIONS; PLACEBO; CELLS; SCALE

Domains: Life Sciences [q-bio]

Aurélie Daumas, Jeremy Magalon, Flore Delaunay, Maxime Abellan, Cécile Philandrianos, et al.. Fat Grafting for Treatment of Facial Scleroderma. Clinics in Plastic Surgery, 2020, 47 (1), pp.155-163. ⟨10.1016/j.cps.2019.08.016⟩. ⟨hal-03226490⟩