Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling

Yves Yeboue (1) , Marion Jean (2) , Gilles Subra (1) , Jean Martinez (1) , Frédéric Lamaty (1) , Thomas-Xavier Métro (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 ISM2 - Institut des Sciences Moléculaires de Marseille

Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.

Domaines: Chimie organique

Yves Yeboue, Marion Jean, Gilles Subra, Jean Martinez, Frédéric Lamaty, et al.. Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling. Organic Letters, 2021, 23 (3), pp.631-635. ⟨10.1021/acs.orglett.0c03209⟩. ⟨hal-03228800⟩